Institutional Repository UDD

Artículos Medicina y Ciencias de la Salud

Artículos Medicina y Ciencias de la Salud

 

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  • Blanco, Alejandro; Morales, Fernanda; Marcelain, Katherine; Harismendy, Olivier; Sjöberg, Marcela; Armisen, Ricardo; de Santiago, Pamela (Elsevier Inc., 2020)
    Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) ...
  • Sánchez, Lucía; Labra, Andrés; Schiappacasse, Giancarlo (Soc. Argentina de Radiología, 2019)
    El colangiocarcinoma (CC) es el segundo tumor primario maligno más frecuente del hígado. La mayor incidencia se registra en Asia y su pronóstico es poco alentador. La resección quirúrgica del tumor es el único tratamiento ...
  • Sagredo, Eduardo; Sagredo, Alfredo; Blanco, Alejandro; Rojas, Pamela; Rivas, Solange; Assar, Rodrigo; Pérez, Paola; Marcelain, Katherine; Armisen, Ricardo (Elsevier B.V., 2020)
    RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
  • Pinto, Mauricio; Córdova-Delgado, Miguel; Retamal, Ignacio; Muñoz-Medel, Matías; Bravo, Loreto; Durán, Doris; Villanueva, Francisco; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Érica, Koch; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Garrido, Marcelo (MDPI, Basel Sz., 2020)
    Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
  • Capelli, Claudio; Sepúlveda, Hugo; Rivas, Solange; Víctor, Paola; Urzúa, Ulises; Donoso, Gerardo; Sagredo, Eduardo; Carrero, David; Casanova-Ortiz, Emmanuel; Sagredo, Alfredo; González, Marisel; Manterola, Marcia; Nardocci, Gino; Armisen, Ricardo; Montecino, Martín; Marcelain, Katherine (Elsevier Ltd., 2020)
    Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
  • Meneses-Salas, Elsa; Garcia-Forn, Marta; Castany-Pladevall, Carla; Lu, Albert; Fajardo, Alba; José, Jaimy; Wahba, Mohamed; Bosch, Marta; Pol, Albert; Tebar, Francesc; Klein, Andrés; Zanlungo, Silvana; Pérez-Navarro, Esther; Grewal, Thomas; Enrich, Carlos; Rentero, Carles (Elsevier Inc./ American Society for Investigative Pathology, 2020)
    Niemann-Pick type C disease (NP-C) is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NP-C disease primarily affects the brain, causing neuronal ...
  • Contreras, Pablo; Tapia, Pablo; González-Hodar, Lila; Peluso, Ivana; Soldati, Chiara; Napoiotano, Gennaro; Matarese, María; Las Heras, Macarena; Valls, Cristian; Martínez, Alexis; Balboa, Elisa; Castro, Juan; Nancy, Leal; Platt, Frances; Sobota, Andrzej; Winter, Dominic; Klein, Andrés; Medina, Diego; Ballabio, Andrea; Alvarez, Alejandra; Zanlungo, Silvana (Cell Press, 2020)
    The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates ...
  • Long, Georgina; Dummer, Reinhard; Hamid, Omid; Gajewski, Thomas; Caglevic, Christian; Dalle, Stephane; Arance, Ana; Carlino, Matteo; Grob, Jean-Jacques Grob; Kim, Tae; Demidov, Lev; Robert, Caroline; Larkin, James; Anderson, James; Maleski, Janet; Jones, Mark; Diede, Scott; Mitchell, Tara (Elsevier Ltd., 2019)
    Background: Immunotherapy combination treatments can improve patient outcomes. Epacadostat, an IDO1 selective inhibitor, and pembrolizumab, a PD-1 inhibitor, showed promising antitumour activity in the phase 1-2 ...
  • Zhao, Yingjie; Diacou, Alexander; Johnston, Richard; Musfee, Fadi; McDonald-McGinn, Donna; McGinn, Daniel; Crowley, Blaine; Repetto, Gabriela; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris; Kates, Wendy; Digilio, Cristina; Unolt, Marta; Marino, Bruno; Pontillo, Maria; Armando, Marco; Di Fabio, Fabio; Vicari, Stefano; van den Bree, Marianne; Moss, Hayley; Owen, Michael; Murphy, Kieran; Murphy, Clodagh; Murphy, Declan; Schoch, Kelly; Shashi, Vandana; Tassone, Flora (American Society of Human Genetics by Elsevier Inc., 2020-01)
    The 22q11.2 deletion syndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22. About 60%-70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have ...
  • Schuh, Christina; Cuenca, Jimena; Alcayaga-Miranda, Francisca; Khoury, Maroun (2019-08)
    Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that ...
  • Barbosa, Pedro; Kaski, Diego; Castro, Patricia; Andrew, Andrew; Warner, Thomas; Djamshidian, Atbin (IOS Press, 2019)
    Fifteen individuals with Parkinson's disease (PD) and impulsive compulsive behaviours (PD+ICB) were compared to 15 PD patients without ICBs (PD-ICB) and 15 healthy controls (HC) on a pro-saccades and an anti-saccades task ...
  • Lobo, Niyati; Shariat, Shahrokh; Guo, Charles; Fernández, Mario; Kassouf, Wassim; Choudhury, Ananya; Gao, Jianjun; Williams, Stephen; Galsky, Matthew; Taylor, John; Roupret, Morgan; Kamat, Ashish (European Association of Urology by Elsevier B.V, 2020-07)
    Context: Urothelial carcinoma can exhibit a wide range of variant morphologies. Many variants present diagnostic challenges and carry clinical implications that inform prognosis and treatment decisions. Objective: To ...
  • Castro, Patricia; Kaski, Diego; Schieppati, Marco; Furman, Michael; Arshad, Qadeer; Bronstein, Adolfo (Elsevier B.V., 2019-02)
    Background: Under static conditions, the objective and subjective measures of postural stability correlate well. However, age-related changes in postural control and task-related anxiety may modify the relationship between ...
  • Carcel, Cheryl; Wang, Xia; Sandset, Else; Delcourt, Candice; Arima, Hisatomi; Lindley, Richard; Hackett, Maree; Lavados, Pablo; Robinson, Thompson; Muñoz-Venturelli, Paula; Olavarría, Verónica; Brunser, Alejandro; Berge, Eivind; Chalmers, John; Woodward, Mark; Anderson, Craig (American Academy of Neurology, 2019-12)
    Objective: To explore the sex differences in outcomes and management after stroke using a large sample with high-quality international trial data. Methods: Individual participant data were obtained from 5 acute stroke ...
  • Bowen, Caitlin; Calderón, Juan Francisco; Burger, Zachary; Rykiel, Graham; Davis, Elaine; Helmers, Mark; Benke, Kelly; Gallo, Elena; Dietz, Harry (American Society for Clinical Investigation., 2020-02)
    Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-α 1 chain of collagen III. Loss of structural integrity ...
  • Urzua, Cristhian; Chen, Ping; Chaigne-Delalande, Benjamin; Liu, Baoying; Anguita, Rodrigo; Guerrero, Julia; Sabat, Pablo; Velásquez, Víctor; Sen, Nida; Lee, Richard; Goecke, Annelise (Elsevier Inc, 2019-11)
    Purpose To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and ...
  • Porte, Lorena; Valdivieso, Francisca; Wilmes, Dunja; Thompson, Luis; Munita, José; Varela, Carmen; Rickerts, Volker; Weitzel, Thomas; Gaete, P; Díaz, MC; Alliende, R (Elsevier Ltd, 2019-08)
    Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, ...
  • Weitzel, Thomas; Vial, Pablo; Perret, Cecilia; Aguilera, Ximena (Elsevier Ltd., 2019-03)
    In recent years, yellow fever (YF) outbreaks have struck various African and South American countries, a scenario, which led to the creation of the “Eliminate Yellow fever Epidemics” initiative by the WHO [1]. The current ...
  • Fernández, Mario; Valdebenito, Patricio; Delgado, Iris; Segebre, Jorge; Chaparro, Eduardo; Fuentealba, David; Castillo, Martín; Vial, Cecilia; Barroso, Juan; Ziegler, Annemarie; Bustamante, Alberto (Elsevier Inc., 2020-02)
    Background: Beyond exposure to arsenic in drinking-water, there is few information about demographic and clinicopathological features of patients with bladder cancer living in arsenic-exposed regions. The aim of the study ...
  • Ivanovic, Daniza; Valenzuela, Rodrigo; Almagia, Atilio; Barrera, Cynthia; Arancibia, Violeta; Larraín, Cristian; Silva, Claudio; Billeke, Pablo; Zamorano, Francisco; Villagrán, Francisca; Orellana, Yasna; Martínez, Víctor (Elsevier Inc., 2019-01)
    Objectives Scholastic achievement (SA) is a multifactorial problem that depends on factors related to the child, the child's family, and the educational system. The aim of this study was to quantify the relative impact ...

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