• Complement Component C3 Participates in Early Stages of Niemann-Pick C Mouse Liver Damage 

  Klein, Andrés; González, Javier; Zanlungo, Silvana (MDPI AG, 2020)

  Niemann-Pick type C (NPC), a lysosomal storage disorder, is mainly caused by mutations in the NPC1 gene. Niemann-Pick type C patients and mice show intracellular cholesterol accumulation leading to hepatic failure with ...
• Health access to immigrants: identifying gaps for social protection in health 

  Cabieses, Báltica; Oyarte, Marcela (Universidade De Sao Paulo. Faculdade De Higiene E Saude Publica, 2020)

  OBJECTIVE To compare the access to and effective use of health services available among international migrants and Chileans. METHODS Secondary analysis of the National Socioeconomic Characterization Survey (CASEN – ...
• Atención inicial de migrantes en Chile: iniciativa en atención primaria de salud a un año de su implementación 

  Chepo, Macarena; Astorga-Pinto, Sofía; Cabieses, Báltica (Pan American Health Organization, 2019)

  Objetivo. Describir las características sociodemográficas, necesidades de salud, derivaciones efectivas realizadas y evaluación inmediata de la población migrante internacional que participó en el Programa de Atención ...
• Meniscus allograft transplantation: indications, techniques and outcomes 

  Figueroa, Francisco; Figueroa, David; Calvo, Rafael; Vaisman, Alex; Espregueira-Mendes, João (British Editorial Society of Bone & Joint Surgery, 2019)

  New indications for meniscal allograft transplantation (MAT) are being added, but the general expert opinion is that it is still a procedure reserved for symptomatic meniscal loss. Lateral MAT has better clinical outcomes ...
• Presoaking of Hamstring Autografts in Vancomycin Decreases the Occurrence of Infection Following Primary Anterior Cruciate Ligament Reconstruction 

  Figueroa, David; Figueroa, Francisco; Calvo, Rafael; López, Mario; Goñi, Ignacio (SAGE Publications, 2019)

  Background: Postoperative septic arthritis is an uncommon but potentially devastating complication after anterior cruciate ligament (ACL) reconstruction. Our group started presoaking grafts with vancomycin to decrease ...
• Osteochondral Autologous Transplantation for Treating Patellar High-Grade Chondral Defects: A Systematic Review 

  Donoso, Rodrigo; Figueroa, David; Espinoza, Jaime; Yáñez, Claudio; Saavedra, Jamil (SAGE Publications, 2019)

  Background: Patellar cartilage defects account for 34.6% of defects found during routine arthroscopy. These defects pose a challenge in orthopaedic surgery because they have been associated with worse outcomes after ...
• ¿Sirven las ayudas técnicas a las personas mayores? Percepción desde la Atención Primaria sobre esta Garantía Explícita en Salud, Santiago, Chile 

  Hirmas, Macarena; Pofald, Lucy; Olea, Andrea; Ximena, Aguilera; Matute, Isabel; González, Claudia; Delgado, Iris; Nájera, Manuel; Gómez, María Inés; Gallardo, Ligia; Bustamante, Hernán; Di Silvestre, María Cristina (Esc. Salud Pública, Universidad de Chile, 2019)

  Objetivo: Conocer la percepción de informantes clave pertenecientes a la red de Atención Primaria de Salud en Chile, respecto al proceso de gestión asistencial y el impacto del programa nacional de Garantías Explícitas en ...
• Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization. 

  Soto, Jorge; Diaz-Dinamarca, Diego; Soto, Daniel; Barrientos, Magaly; Carrión, Flavio; Kalergis, Alexis; Vásquez, Abel (Elsevier Ltd, 2019)

  Group B Streptococcus (GBS) represents one of the most common causes of bacterial infection in neonates; it is also associated with premature childbirth and stillbirth. A vaccine against GBS is needed, but no approved ...
• Imágenes en divertículos del tubo digestivo: Localizaciones infrecuentes. Serie de casos 

  Whittle, Carolina; Schiappacasse, Giancarlo; Leal, Ema; Franz, Gerhard; Hasson, Daniel; Maldonado, Ignacio; Cortes, Claudio (Sociedad Chilena de Radiología, 2018)

  Los divertículos se pueden localizar en todo el tubo digestivo (TD): esófago, estómago, duodeno, yeyuno, íleon, apéndice, colon. Son infrecuentes, salvo en colon. Sus manifestaciones clínicas son inespecíficas, con difícil ...
• New Use of Rapamycin Stent in Non-Responding Facial Lymphatic Malformation 

  Vargas, Patricio; Whittle, Carolina; Recule, Francisca; Fajre, Ximena (BJSTR Pub., 2019)

  Introduction: Vascular anomalies represent a diagnostic and therapeutic difficulty. A lymphatic malformation (LM) corresponds to a low-flow vascular malformation. Sclerotherapy is the preferred treatment. Recently, ...
• Aspirin and N‐acetylcysteine co‐administration markedly inhibit chronic ethanol intake and block relapse binge drinking: Role of neuroinflammation‐oxidative stress self‐perpetuation 

  Israel, Yedy; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Santapau, Daniela; Berríos-Cárcamo, Pablo; Ezquer, Marcelo; Olivares, Belen; Herrera-Marschitz, Mario (2020)

  Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in alterations that perpetuate alcohol intake and cued-relapse. Studies show that brain oxidative stress is consistently associated with ...
• Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking. 

  Ezquer, Fernando; Quintanilla, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan, Marcelo J.; Salas-Huenuleo, Edison; Herrera-Marschitz, Mario; Israel, Yedy (2020)

  Chronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that neuroinflammation results in increases in chronic ...
• Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options 

  Israel, Yedy; Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Rivera-Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera-Marschitz, Mario (2020)

  Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
• Intranasal mesenchymal stem cell secretome administration markedly inhibits alcohol and nicotine self-administration and blocks relapse-intake: mechanism and translational options 

  Quintanilla, María Elena; Ezquer, Fernando; Morales, Paola; Santapau, Daniela; Berríos-Cárcamo, Pablo; Ezquer, Marcelo; Herrera-Marschitz, Mario; Israel, Yedy (2019)

  Background: Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at ...
• Identification of Rigosertib for the Treatment of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma. 

  Atanasova, Velina S.; Pourreyron, Celine; Farshchian, Mehdi; Christian A., Brown IV; Watt, Stephen A.; Wright, Sheila; Warkala, Michael; Guttmann-Gruber, Christina; Piñón Hofbauer, Josefina; Fuentes, Ignacia; Prisco, Marco; Rashidghamat, Elham; Has, Cristina; Palisson, Francis; Hovnanian, Alain; McGrath, John A.; Mellerio, Jemima E.; Bauer, Johann; South, Andrew P. (2019)

  Purpose: Squamous cell carcinoma (SCC) of the skin is the leading cause of death in patients with the severe generalized form of the genetic disease recessive dystrophic epidermolysis bullosa (RDEB). Although emerging data ...
• Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection 

  Ribeiro, Grazielle; León, Luis; Pérez, Ruth; Cuiza, Analía; Vial, Pablo; Ferres, Marcela; Mertz, Gregory; Vial, Cecilia (2019)

  Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others ...
• A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility 

  Martínez-Valdebenito, Constanza; Angulo, Jenniffer; Corre, Nicole Le; Marco, Claudia; Vial, Cecilia; Miquel, Juan Francisco; Cerda, Jaime; Mertz, Gregory; Vial, Pablo; Lopez-Lastra, Marcelo; Ferrés, Marcela (2019)

  The Andes Orthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. ...
• Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation 

  Hoste, Esther; Maueröder, Christian; Hove, Lisette van; Catrysse, Leen; Vikkula, Hanna-Kaiza; Sze, Mozes; Maes, Bastiaan; Karjosukarso, Dyah; Martens, Liesbet; Goncalves, Amanda; Parthoens, Eef; Roelandt, Ria; Declercq, Wim; Fuentes, Ignacia; Palisson, Francis; Gonzalez, Sergio; Salas-Alanis, Julio C.; Boon, Louis; Huebener, Peter; Mulder, Klaas Willem; Ravichandran, Kodi; Saeys, Yvan; Schwabe, Robert Felix; Loo, Geert van (2019)

  Regenerative responses predispose tissues to tumor formation by largely unknown mechanisms. High-mobility group box 1 (HMGB1) is a dangerassociated molecular pattern contributing to inflammatory pathologies. We show that ...
• Epidermolysis bullosa simplex-generalized severe due to p.Glu477Lys mutation in keratin 5: a genotype-phenotype correlation with in silico modeling analysis 

  Lalor, Leah; Titeux, Matthias; Palisson, Francis; Fuentes, Ignacia; Yubero, María; Tasanen, Kaisa; Huilaja, Laura; Has, Cristina; Tadini, Gianluca; Haggstrom, Anita N.; Hovnanian, Alain; Lucky, Anne W. (2019)

  Background/Objectives: Epidermolysis bullosa is a group of diseases caused by mutations in skin structural proteins. Availability of genetic sequencing makes identification of causative mutations easier, and genotype‐phenotype ...
• Epidermolysis bullosa simplex with KLHL24 mutations is associated with dilated cardiomyopathy 

  Schwieger-Briel, A.; Fuentes, Ignacia; Castiglia, D.; Barbato, A.; Greutmann, M.; Leppert, J.; Duchatelet, S.; Hovnanian, A.; Burattini, S.; Yubero, María; Ibañez-Arenas, Rodrigo; Rebolledo-Jaramillo, B.; Gräni, C.; Ott, H.; Theiler, M.; Weibel, L.; Paller, A.S.; Zambruno, G.; Fischer, J.; Palisson, Francis; Has, C. (2019)

  Inherited epidermolysis bullosa (EB) comprises rare heterogeneous disorders characterized by cutaneous and mucosal fragility. Most of the 20 proteins affected have structural functions. Recently, a previously undescribed ...

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