• Statistical Analysis plan of the Head Position in acute ischemic Stroke Trial pilot 

  Olavarría, Verónica V.; Arima, Hisatomi; Anderson, Craig S.; Muñoz-Venturelli, Paula; Billot, Laurent; Lavados, Pablo M.; Brunser, Alejandro M. (2017)

  Background: The HEADPOST Pilot is a proof of concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat ...
• Flat-head positioning increases cerebral blood flow in anterior circulation acute ischemic stroke. A cluster randomized phase IIb trial. 

  Lavados, Pablo M.; Muñoz-Venturelli, Paula; González, Francisca; Olavarría, Verónica V.; Gaete, Javier; Martins, Sheila; Arima, Hisatomi; Anderson, Craig S.; Brunser, Alejandro M. (2018)

  Background. Whether lying-flat improves blood flow in patients with acute ischemic stroke (AIS) is unknown. Our aim was to investigate if lying-flat ‘changes’ cerebral blood flow velocities (CBFV) assessed by transcranial ...
• Effects of 24-hours/day versus business hours physical therapy intervention in adult intensive care unit patients: a systematic review care unit patients 

  Merino, Catalina; Castro-Ávila, Ana Cristina; Gutiérrez-Arias, Ruvistay; Arriagada, María Jesús; Villanueva, Catalina; Leppe, Jaime; Fu, Carolina (2018)

  Background: Some evidence suggests that higher doses of mobilization could have benefits on functional status. However, the impact of increasing the availability of Physical Therapist in the intensive care unit to provide ...
• Chilean version of the Functional Status Score for the Intensive Care Unit: a translation and cross-cultural adaptation 

  González-Seguel, Felipe; Camus-Molina, Agustín; Leppe, Jaime; Hidalgo-Cabalín, Viviane; Gutiérrez-Panchana, Tania; Needham, Dale; Guimaraes, Fernando (2019)

  Background: The Functional Status Score for the Intensive Care Unit (FSS-ICU) is a valid and reliable instrument to measure physical functioning in the intensive care unit setting. Translation and cross-cultural adaptation ...
• International Classification of Functioning, Disability, and Health Domains of 60 Physical Functioning Measurement Instruments Used During the Adult Intensive Care Unit Stay: A Scoping Review. 

  González-Seguel, Felipe; Corner, Evelyn; Merino, Catalina (2019)

  BACKGROUND: There has been a recent surge in the creation and adaptation of instruments to measure physical functioning (PF) in the intensive care unit (ICU). Selecting the right measurement instrument depends on ...
• Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. 

  Retamal, Mauricio; Orellana, Viviana; Arévalo, Nicolás; Rojas, Cristóbal; Arjona, Rodolfo; Alcaíno, Constanza; González, Wendy; Canan, Jonathan; Moraga-Amaro, Rodrigo; Stehberg, Jimmy; Reuss, Luis; Altenberg, Guillermo (2019)

  Under normal conditions, connexin (Cx) hemichannels have a low open probability, which can increase under pathological conditions. Since hemichannels are permeable to relatively large molecules, their exacerbated activity ...
• Effects of phaseolus vulgaris extract on lipolytic activity and differentiation of 3T3-L1 preadipocytes into mature adipocytes: a strategy to prevent obesity 

  Castillo, Felipe; González, Daniel R.; Moore-Carrasco, Rodrigo (2019)

  Background. Overweight and obesity are defined as abnormal or excessive fat accumulation that may be harmful for health. A global trend in this area is the search for natural compounds that have a proven beneficial effect ...
• Complement-activating donor-specific anti- HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis 

  Bouquegneau, Antoine; Loheac, Charlotte; Aubert, Olivier; Bouatou, Yassine; Viglietti, Denis; Empana, Jean-Philippe; Ulloa, Camilo; Hassan Murad, Mohammad; Legendre, Christophe; Glotz, Denis; Jackson, Annette M.; Zeevi, Adriana; Schaub, Stephan; Taupin, Jean-Luc; Reed, Elaine F.; Friedewald, John J.; Tyan, Dolly B.; Süsal, Caner; Shapiro, Ron; Woodle, E. Steve; Hidalgo, Luis G.; O'Leary, Jacqueline; Montgomery, Robert A.; Kobashigawa, Jon; Jouven, Xavier; Jabre, Patricia; Lefaucheur, Carmen; Loupy, Alexandre (2018)

  Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure. The capacity of circulating anti-HLA ...
• Settings and monitoring of mechanical ventilation during physical therapy in adult critically ill patients: protocol for a scoping review 

  González-Seguel, Felipe; Camus-Molina, Agustín; Jasmén Sepúlveda, Anita; Pérez Araos, Rodrigo; Molina Blamey, Jorge; Graf Santos, Jerónimo (2019)

  Introduction Early mobilisation has been extensively advocated to improve functional outcomes in critically ill patients, even though consistent evidence of its benefits has remained elusive. These conflicting results could ...
• Music Therapy for Pain and Anxiety Management in Nasal Bone Fracture Reduction: Randomized Controlled Clinical Trial 

  Ortega, Alvaro; Gauna, Felipe; Munoz, Daniel; Oberreuter, Gerardo; Breinbauer, Hayo; Carrasco, Loreto (2019)

  Objective: To evaluate whether listening to music through binaural headphones contributes to the perception of pain and anxiety in patients undergoing closed nasal bone fracture reductions. Study Design: Randomized ...
• Características clínicas de 63 pacientes con ataxia 

  Saffie Awad, Paula; Vial Undurraga, Felipe; Chaná-Cuevas, Pedro (2018)

  Background: Ataxia can be classified as genetic, sporadic or acquired. Aim: To report the clinical features of a group of patients with ataxia. Material and Methods: Review of medical records of patients consulting in a ...
• Mastoid osteoma in a prehispanic cranium (1390 A.D.) from northern Chile 

  Castro, Mario; Goycoolea, Marcos; Gálvez, Marcelo; Silva-Pinto, Verónica; Montoya, Carlos; Fuentes, Jorge (2019)

  Objective: Osteomas are slow-growing benign tumors that can affect the skull, most frequently the parietal and frontal. Temporal bone osteomas are more common in the external acoustic meatus and exceptional in the mastoid ...
• The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice 

  Mayo, Tomás de; Conget, Paulette; Becerra-Bayona, Silvia; Sossa, Claudia L.; Galvis, Virgilio; Arango-Rodríguez, Martha L. (2017)

  Mesenchymal stromal cells (MSCs) have shown to be a promising tool in cell therapies to treat different conditions. Several pre-clinical and clinical studies have proved that the transplantation of MSCs improves wound ...
• Research on migration and health in Chile: pushing forward 

  Cabieses, Báltica (2016)
• A novel exaggerated "Spino-bulbo-spinal like" reflex of lower brainstem origin 

  Merchant, Shabbir Hussain; Vial, Felipe; Leodori, Giorgio; Fahn, Stanley; Pullman, Seth; Hallett, Mark (2019)

  Background: Many different oligosynaptic reflexes are known to originate in the lower brainstem which share phenomenological and neurophysiological similarities. Objective: To evaluate and discuss the differences and ...
• Secondary spontaneous pneumothorax in patients with sarcoma treated with Pazopanib, a case control study 

  Sabath, Bruce; Muhammad, Hasan A.; Balagani, Amulya; Ost, David E.; Vakil, Erik; Ahmed, Tahreem; Vial, Macarena R .; Grosu, Horiana B. (2018)

  Background: The tyrosine kinase inhibitor pazopanib is used for treatment of sarcoma. Recent studies have suggested that the use of pazopanib may lead to the development of pneumothorax, an unexpected adverse effect in ...
• Novel Heterozygous Mutation in NFKB2 Is Associated With Early Onset CVID and a Functional Defect in NK Cells Complicated by Disseminated CMV Infection and Severe Nephrotic Syndrome 

  Aird, Alejandra; Lagos, Macarena; Vargas-Hernández, Alexander; Posey, Jennifer; Coban-Akdemir, Zeynep; Jhangiani, Shalini; Mace, Emily; Reyes, Anaid; King, Alejandra; Cavagnaro, Felipe; Forbes, Lisa; Chinn, Iván; Lupski, James; Orange, Jordan; Poli, María Cecilia (2019)

  Nuclear factor kappa-B subunit 2 (NF-κB2/p100/p52), encoded by NFKB2 (MIM: 164012) belongs to the NF-κB family of transcription factors that play a critical role in inflammation, immunity, cell proliferation, differentiation ...
• Platelet Count in Patients with Mild Disease at Admission is Associated with Progression to Severe Hantavirus Cardiopulmonary Syndrome 

  López, René; Vial, Cecilia; Graf, Jerónimo; Calvo, Mario; Ferrés, Marcela; Mertz, Gregory; Cuiza, Analía; Agüero, Begonia; Aguilera, Dante; Araya, Diego; Pailamilla, Ignacia; Paratori, Flavia; Torres-Torres, Víctor; Vial, Pablo; HantavirusStudy Group in Chile (2019)

  BACKGROUND: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35-40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was ...
• Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease 

  Vejar, Sebastián; Oyarzún, Juan; Retamal, Mauricio; Ortiz, Fernando; Juan, Orellana (2019)

  Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information ...
• Assistive Devices for Older Adults: A Longitudinal Study of Policy Effectiveness, Santiago, Chile, 2014–2016 

  Hirmas, Macarena; Olea, Andrea; Matute, Isabel; Delgado, Iris; Aguilera, Ximena; Poffald, Lucy; González, Claudia; Nájera, Manuel; Gómez, María Inés; Gallardo, Ligia; Abusleme, María Teresa; Leppe, Jaime; Mery, Hernán; Recabarren, Eladio; Massad, Cristián; Bustamante, Hernán (2019)

  INTRODUCTION Population aging is a worldwide phenomenon. It is estimated that by 2050, one of five persons will be aged ≥60 years. In Chile, 15.8% of the population is now aged ≥60 years, and this figure will reach 30.7% ...

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