Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus
Date
2020
Type:
Article
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7 p.
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Abstract
Purpose: To evaluate the different definition of refractoriness in uveitis in the literature.
Methods: We systematically searched the literature in order to identify definitions of refractory noninfectious uveitis in adult patients. A search strategy in the databases of MEDLINE and Scopus was used to find articles published between January 2005 and October 2018.
Results: Definitions of corticosteroids-refractoriness were related to two main concepts: persistence of inflammation despite the use of corticosteroid and recurrences above a dosage threshold. In terms of immunomodulatory therapy and biologic agents, we observed a great variety of definitions: persistence of inflammation, number of attacks, side effects or complications, symptoms, and best-corrected visual acuity.
Conclusions: The results of this systematic review demonstrate the current lack of consensus on the definition for refractory uveitis, regardless of the treatment being used and revealed a new terminology based on a comprehensive and operational definition for each specific category of refractoriness.
Description
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Citation
Ocular Immunology and Inflammation. 2020 Sep 4;1-6
Keywords
Resistant, Biologics, Consensus, Definition, Glucocorticoids, Immunomodulatory, Intractable, Refractory, Uveitis treatment