Definition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensus

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dc.contributor.authorValenzuela, Rodrigo A.
dc.contributor.authorFlores, Iván
dc.contributor.authorPujol, Myriam
dc.contributor.authorLlanos, Carolina
dc.contributor.authorCarreño, Ester
dc.contributor.authorRada, Gabriel
dc.contributor.authorHerbort Jr, Carl P.
dc.contributor.authorCuitino, Loreto
dc.contributor.authorUrzúa, Cristhian
dc.date.accessioned2021-08-20T14:13:48Z
dc.date.available2021-08-20T14:13:48Z
dc.date.issued2020
dc.description.abstractPurpose: To evaluate the different definition of refractoriness in uveitis in the literature. Methods: We systematically searched the literature in order to identify definitions of refractory noninfectious uveitis in adult patients. A search strategy in the databases of MEDLINE and Scopus was used to find articles published between January 2005 and October 2018. Results: Definitions of corticosteroids-refractoriness were related to two main concepts: persistence of inflammation despite the use of corticosteroid and recurrences above a dosage threshold. In terms of immunomodulatory therapy and biologic agents, we observed a great variety of definitions: persistence of inflammation, number of attacks, side effects or complications, symptoms, and best-corrected visual acuity. Conclusions: The results of this systematic review demonstrate the current lack of consensus on the definition for refractory uveitis, regardless of the treatment being used and revealed a new terminology based on a comprehensive and operational definition for each specific category of refractoriness.es
dc.format.extent7 p.es
dc.identifier.citationOcular Immunology and Inflammation. 2020 Sep 4;1-6es
dc.identifier.urihttps://doi.org/10.1080/09273948.2020.1793369es
dc.identifier.urihttp://hdl.handle.net/11447/4384
dc.language.isoenes
dc.subjectResistantes
dc.subjectBiologicses
dc.subjectConsensuses
dc.subjectDefinitiones
dc.subjectGlucocorticoidses
dc.subjectImmunomodulatoryes
dc.subjectIntractablees
dc.subjectRefractoryes
dc.subjectUveitis treatmentes
dc.titleDefinition of Uveitis Refractory to Treatment: A Systematic Review in the Absence of a Consensuses
dc.typeArticlees

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