Association of retinal detachment with age 50 years or younger at onset in patients with acute retinal necrosis
Date
2021
Type:
Article
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Abstract
Background Due to the guarded prognosis of acute retinal necrosis (ARN), it is relevant to develop a strategy to earlycategorize those patients in a higher risk of worse outcomes. The purpose of this study is to describe clinical features andpredictive factors for retinal detachment (RD) in patients with ARN.
Methods Retrospective observational case series of 34 adult patients (38 eyes) with ARN examined between January 2005 and July 2015 in the National Eye Institute (Bethesda, USA), the Department of Ophthalmology, University of Chile (Santiago, Chile), and APEC (CDMX, Mexico).
Results A total of 16 males and 18 females with a mean age at presentation of 44.5±16.8 years were included. Twentyseven patients (79.4%) received intravenous acyclovir as frst-line treatment, and 7 patients received either oral antiviral (4
patients) or oral plus intravitreal antiviral (3 patients). All subjects were treated with prednisone, with a mean initial dose of 57.7±16.3 mg per day. Seventeen patients (50.0%) developed retinal detachment. An association of retinal detachment with
age at onset was observed (p=0.04), with patients younger than 50 years presenting a higher risk (OR=14.86, p=0.0009). Additionally, patients in this higher risk group had more infammation in both anterior chamber and vitreous (p=0.04 and
0.03, respectively). No other predictive factor for retinal detachment was found in the present study.
Conclusions RD represents an important complication in patients with ARN. Younger patients may be at higher risk of this complication, possibly secondary to the presence of a higher level of infammation.
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Citation
rzua CA, Knickelbein J, Cuitino L, Moreno U, Anguita R, Velasquez V, Concha-Del-Rio LE, Morales S, Villarroel FA, Sen HN, Arellanes-Garcia L. Association of retinal detachment with age 50 years or younger at onset in patients with acute retinal necrosis. Graefes Arch Clin Exp Ophthalmol. 2021 Oct;259(10):2905-2911. doi: 10.1007/s00417-021-05166-4
Keywords
Acute retinal necrosis, Predictive factors, Retinal detachment, Younger age