Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus

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dc.contributor.authorGonzález-Gronow, Mario
dc.contributor.authorCuchacovich, Miguel
dc.contributor.authorFrancos, Rina
dc.contributor.authorCuchacovich, Stephanie
dc.contributor.authorBlanco, Ángel
dc.contributor.authorSandoval, Rodrigo
dc.contributor.authorFarías Gómez, Cristian
dc.contributor.authorValenzuela, Javier A.
dc.contributor.authorRay, Rupa
dc.contributor.authorPizzo, Salvatore V.
dc.date.accessioned2016-10-24T21:11:21Z
dc.date.available2016-10-24T21:11:21Z
dc.date.issued2015
dc.description.abstractAutoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats either perfused with or previously inoculated with this IgA. Because this class of autoantibody causes myelin sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD.
dc.identifier.citationGonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Blanco A, Sandoval R, Gomez CF, Valenzuela JA, Ray R, Pizzo SV. Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. J Neuroimmunol. 2015 Oct 15;287:1-8
dc.identifier.urihttp://hdl.handle.net/11447/791
dc.identifier.urihttp://dx.doi.org/10.1016/j.jneuroim.2015.07.006
dc.language.isoen_US
dc.subjectAutism
dc.subjectAutoimmunity
dc.subjectMyelin basic protein
dc.subjectProtease antibodies
dc.subjectSynaptic plasticity
dc.subjectRat hippocampi
dc.titleCatalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
dc.typeArtículo

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