Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus

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Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.pdf (722.12 KB)

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2015

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Artículos Educación

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http://hdl.handle.net/11447/791
 http://dx.doi.org/10.1016/j.jneuroim.2015.07.006

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Abstract

Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantib...

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Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Blanco A, Sandoval R, Gomez CF, Valenzuela JA, Ray R, Pizzo SV. Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. J Neuroimmunol. 2015 Oct 15;287:1-8

Keywords

Autism , Autoimmunity , Myelin basic protein , Protease antibodies , Synaptic plasticity , Rat hippocampi

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