Human Anterior Insula Encodes Performance Feedback and Relays Prediction Error to the Medial Prefrontal Cortex

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dc.contributor.authorBilleke, Pablo
dc.contributor.authorOssandon, Tomas
dc.contributor.authorPerrone-Bertolotti, Marcela
dc.contributor.authorKahane, Philippe
dc.contributor.authorBastin, Julien
dc.contributor.authorJerbi, Karim
dc.contributor.authorLachaux, Jean-Philippe
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2021-07-13T16:05:10Z
dc.date.available2021-07-13T16:05:10Z
dc.date.issued2020
dc.description.abstractAdaptive behavior requires the comparison of outcome predictions with actual outcomes (e.g., performance feedback). This process of performance monitoring is computed by a distributed brain network comprising the medial prefrontal cortex (mPFC) and the anterior insular cortex (AIC). Despite being consistently co-activated during different tasks, the precise neuronal computations of each region and their interactions remain elusive. In order to assess the neural mechanism by which the AIC processes performance feedback, we recorded AIC electrophysiological activity in humans. We found that the AIC beta oscillations amplitude is modulated by the probability of performance feedback valence (positive or negative) given the context (task and condition difficulty). Furthermore, the valence of feedback was encoded by delta waves phase-modulating the power of beta oscillations. Finally, connectivity and causal analysis showed that beta oscillations relay feedback information signals to the mPFC. These results reveal that structured oscillatory activity in the anterior insula encodes performance feedback information, thus coordinating brain circuits related to reward-based learning.es
dc.format.extent15 p.es
dc.identifier.citationCerebral Cortex, Volume 30, Issue 7, July 2020, Pages 4011–4025es
dc.identifier.urihttps://doi.org/10.1093/cercor/bhaa017es
dc.identifier.urihttp://hdl.handle.net/11447/4161
dc.language.isoenes
dc.subjectBeta oscillationses
dc.subjectError monitoringes
dc.subjectFeedbackes
dc.subjectInsulaes
dc.subjectIntracortical recordinges
dc.titleHuman Anterior Insula Encodes Performance Feedback and Relays Prediction Error to the Medial Prefrontal Cortexes
dc.typeArticlees

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