Therapeutic effects of mesenchymal stem cell-derived secretome administration on morphine-induced consumption, relapse, and withdrawal in rats: Role of brain oxidative stress and neuroinflammation
Date
2023
Type:
Thesis
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97 p.
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Acceso abierto
Authors
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Publisher
Universidad del Desarrollo. Facultad de Medicina
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Abstract
This thesis presents the results obtained after the simultaneous intranasal and intravenous administration of the antioxidant and anti-inflammatory secretome generated from preconditioned hMSC on the precipitated (naloxone-induced) and spontaneous (oral model) withdrawal syndrome, the reduction in its chronic consumption, and the relapse to voluntary oral consumption (oral model) in rats exposed to continuous doses of opioids. Additionally, the association and role of oxidative stress and neuroinflammation in the different stages of morphine addiction were evaluated.
Description
Thesis presented to the School of Medicine Clínica Alemana-Universidad del Desarrollo in order to apply for doctoral degree (PhD) in Sciences and Innovation in Medicine
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Citation
Keywords
090036S, Mesenchymal, Secretome, Neuroinflammation