Therapeutic effects of mesenchymal stem cell-derived secretome administration on morphine-induced consumption, relapse, and withdrawal in rats: Role of brain oxidative stress and neuroinflammation

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dc.contributor.advisorEzquer, Fernando
dc.contributor.advisorBerríos-Cárcamo, Pablo
dc.contributor.authorQuezada Diez, Mauricio Alejandro
dc.date.accessioned2023-10-25T15:48:39Z
dc.date.available2023-10-25T15:48:39Z
dc.date.issued2023
dc.descriptionThesis presented to the School of Medicine Clínica Alemana-Universidad del Desarrollo in order to apply for doctoral degree (PhD) in Sciences and Innovation in Medicine
dc.description.abstractThis thesis presents the results obtained after the simultaneous intranasal and intravenous administration of the antioxidant and anti-inflammatory secretome generated from preconditioned hMSC on the precipitated (naloxone-induced) and spontaneous (oral model) withdrawal syndrome, the reduction in its chronic consumption, and the relapse to voluntary oral consumption (oral model) in rats exposed to continuous doses of opioids. Additionally, the association and role of oxidative stress and neuroinflammation in the different stages of morphine addiction were evaluated.
dc.format.extent97 p.
dc.identifier.doihttp://doi.org/10.52611/11447/8021
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/8021
dc.language.isoen
dc.publisherUniversidad del Desarrollo. Facultad de Medicina
dc.subject090036S
dc.subjectMesenchymal
dc.subjectSecretome
dc.subjectNeuroinflammation
dc.titleTherapeutic effects of mesenchymal stem cell-derived secretome administration on morphine-induced consumption, relapse, and withdrawal in rats: Role of brain oxidative stress and neuroinflammation
dc.typeThesis
dcterms.accessRightsAcceso abierto

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