Institutional Repository UDD

Dirección de Investigación

Dirección de Investigación

 

Artículos, documentos de trabajo y otros documentos de investigación / Articles, working papers and other research papers

Sub-communities within this community

Collections in this community

Recent Submissions

  • Long, Georgina; Dummer, Reinhard; Hamid, Omid; Gajewski, Thomas; Caglevic, Christian; Dalle, Stephane; Arance, Ana; Carlino, Matteo; Grob, Jean-Jacques Grob; Kim, Tae; Demidov, Lev; Robert, Caroline; Larkin, James; Anderson, James; Maleski, Janet; Jones, Mark; Diede, Scott; Mitchell, Tara (Elsevier Ltd., 2019)
    Background: Immunotherapy combination treatments can improve patient outcomes. Epacadostat, an IDO1 selective inhibitor, and pembrolizumab, a PD-1 inhibitor, showed promising antitumour activity in the phase 1-2 ...
  • Zhao, Yingjie; Diacou, Alexander; Johnston, Richard; Musfee, Fadi; McDonald-McGinn, Donna; McGinn, Daniel; Crowley, Blaine; Repetto, Gabriela; Swillen, Ann; Breckpot, Jeroen; Vermeesch, Joris; Kates, Wendy; Digilio, Cristina; Unolt, Marta; Marino, Bruno; Pontillo, Maria; Armando, Marco; Di Fabio, Fabio; Vicari, Stefano; van den Bree, Marianne; Moss, Hayley; Owen, Michael; Murphy, Kieran; Murphy, Clodagh; Murphy, Declan; Schoch, Kelly; Shashi, Vandana; Tassone, Flora (American Society of Human Genetics by Elsevier Inc., 2020-01)
    The 22q11.2 deletion syndrome (22q11.2DS) results from non-allelic homologous recombination between low-copy repeats termed LCR22. About 60%-70% of individuals with the typical 3 megabase (Mb) deletion from LCR22A-D have ...
  • Schuh, Christina; Cuenca, Jimena; Alcayaga-Miranda, Francisca; Khoury, Maroun (2019-08)
    Over the last decades exosomes have become increasingly popular in the field of medicine. While until recently they were believed to be involved in the removal of obsolete particles from the cell, it is now known that ...
  • Barbosa, Pedro; Kaski, Diego; Castro, Patricia; Andrew, Andrew; Warner, Thomas; Djamshidian, Atbin (IOS Press, 2019)
    Fifteen individuals with Parkinson's disease (PD) and impulsive compulsive behaviours (PD+ICB) were compared to 15 PD patients without ICBs (PD-ICB) and 15 healthy controls (HC) on a pro-saccades and an anti-saccades task ...
  • Lobo, Niyati; Shariat, Shahrokh; Guo, Charles; Fernández, Mario; Kassouf, Wassim; Choudhury, Ananya; Gao, Jianjun; Williams, Stephen; Galsky, Matthew; Taylor, John; Roupret, Morgan; Kamat, Ashish (European Association of Urology by Elsevier B.V, 2020-07)
    Context: Urothelial carcinoma can exhibit a wide range of variant morphologies. Many variants present diagnostic challenges and carry clinical implications that inform prognosis and treatment decisions. Objective: To ...
  • Castro, Patricia; Kaski, Diego; Schieppati, Marco; Furman, Michael; Arshad, Qadeer; Bronstein, Adolfo (Elsevier B.V., 2019-02)
    Background: Under static conditions, the objective and subjective measures of postural stability correlate well. However, age-related changes in postural control and task-related anxiety may modify the relationship between ...
  • Carcel, Cheryl; Wang, Xia; Sandset, Else; Delcourt, Candice; Arima, Hisatomi; Lindley, Richard; Hackett, Maree; Lavados, Pablo; Robinson, Thompson; Muñoz-Venturelli, Paula; Olavarría, Verónica; Brunser, Alejandro; Berge, Eivind; Chalmers, John; Woodward, Mark; Anderson, Craig (American Academy of Neurology, 2019-12)
    Objective: To explore the sex differences in outcomes and management after stroke using a large sample with high-quality international trial data. Methods: Individual participant data were obtained from 5 acute stroke ...
  • Bowen, Caitlin; Calderón, Juan Francisco; Burger, Zachary; Rykiel, Graham; Davis, Elaine; Helmers, Mark; Benke, Kelly; Gallo, Elena; Dietz, Harry (American Society for Clinical Investigation., 2020-02)
    Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-α 1 chain of collagen III. Loss of structural integrity ...
  • Urzua, Cristhian; Chen, Ping; Chaigne-Delalande, Benjamin; Liu, Baoying; Anguita, Rodrigo; Guerrero, Julia; Sabat, Pablo; Velásquez, Víctor; Sen, Nida; Lee, Richard; Goecke, Annelise (Elsevier Inc, 2019-11)
    Purpose To investigate the potential of utilizing the expression of genes for glucocorticoid receptor (GR) and mitogen-activated protein kinase phosphatase-1 (MKP-1) as biomarkers of corticosteroid (CS) refractoriness and ...
  • Porte, Lorena; Valdivieso, Francisca; Wilmes, Dunja; Thompson, Luis; Munita, José; Varela, Carmen; Rickerts, Volker; Weitzel, Thomas; Gaete, P; Díaz, MC; Alliende, R (Elsevier Ltd, 2019-08)
    Coccidioides is a primary pathogenic fungus, which infects humans through highly infectious arthroconidia, causing substantial morbidity including life-threatening disseminated infections. Due to the low infectious dose, ...
  • Weitzel, Thomas; Vial, Pablo; Perret, Cecilia; Aguilera, Ximena (Elsevier Ltd., 2019-03)
    In recent years, yellow fever (YF) outbreaks have struck various African and South American countries, a scenario, which led to the creation of the “Eliminate Yellow fever Epidemics” initiative by the WHO [1]. The current ...
  • Fernández, Mario; Valdebenito, Patricio; Delgado, Iris; Segebre, Jorge; Chaparro, Eduardo; Fuentealba, David; Castillo, Martín; Vial, Cecilia; Barroso, Juan; Ziegler, Annemarie; Bustamante, Alberto (Elsevier Inc., 2020-02)
    Background: Beyond exposure to arsenic in drinking-water, there is few information about demographic and clinicopathological features of patients with bladder cancer living in arsenic-exposed regions. The aim of the study ...
  • Ivanovic, Daniza; Valenzuela, Rodrigo; Almagia, Atilio; Barrera, Cynthia; Arancibia, Violeta; Larraín, Cristian; Silva, Claudio; Billeke, Pablo; Zamorano, Francisco; Villagrán, Francisca; Orellana, Yasna; Martínez, Víctor (Elsevier Inc., 2019-01)
    Objectives Scholastic achievement (SA) is a multifactorial problem that depends on factors related to the child, the child's family, and the educational system. The aim of this study was to quantify the relative impact ...
  • Carvajal-Hausdorf, Daniel; Patsenker, Jonathan; Stanton, Kelly; Villarroel-Espindola, Franz; Esch, Amanda; Montgomery, Montgomery; Psyrri, Amanda; Kalogeras, Konstantine; Kotoula, Vassiliki; Foutzilas, George; Schalper, Kurt; Kluger, Yuval; Rimm, David (American Association for Cancer Research., 2019-05)
    Purpose: Imaging mass cytometry (IMC) uses metal-conjugated antibodies to provide multidimensional, objective measurement of protein targets. We used this high-throughput platform to perform an 18-plex assessment of HER2 ...
  • Altan, Mehmet; Toki, Maria; Gettinger, Scott; Carvajal-Hausdorf, Daniel; Zugazagoitia, Jon; Sinard, John; Herbst, Roy; Rimm, David (Elsevier Inc., 2019-06)
    Side effects of immune checkpoint inhibitors, termed immune-related adverse events, are relatively common, but immune checkpoint inhibitor-mediated cardiotoxicities are rare; however, they can be serious and potentially ...
  • Tapia-Muñoz, Thamara; Slachevsky, Andrea; León-Campos, María; Madrid, Michel; Caqueo-Urizar, Alejandra; Rohde, Gustav; Miranda-Castillo, Claudia (BioMed Central Ltd, 2019-04)
    Background The needs of people with dementia (PWD) have not been assessed in any Latin American country. Several European countries have already related unmet needs with quality of life, caregiver’s age, burden, stress, ...
  • Slachevsky, Andrea; Forno, Gonzalo; Barraza, Paulo; Mioshi, Eneida; Delgado, Carolina; Lillo, Patricia; Henríquez, Fernando; Bravo, Eduardo; Farias, Mauricio; Muñoz-Neira, Carlos; Ibáñez, Agustín; Parra, Mario; Hornberger, Michael (Springer Nature, 2019-06)
    Background: Impairments in activities of daily living (ADL) are a criterion for Alzheimer's disease (AD) dementia. However, ADL gradually decline in AD, impacting on advanced (a-ADL, complex interpersonal or social ...
  • Riveros, Rodrigo; Bakchine, Serge; Pillon, Bernard; Poupon, Fabrice; Miranda, Marcelo; Slachevsky, Andrea (Frontiers Ed., 2019-01)
    In humans and non-humans primates, extensive evidence supports the existence of subcortico-cortical circuits for cognition and behavior. Lesions studies are critical to understand the clinical significance of these ...
  • Tapia-Castillo, Alejandra; Baudrand, Rene; Vaidya, Anand; Campino, Carmen; Allende, Fidel; Valdivia, Carolina; Vecchiola, Andrea; Lagos, Carlos; Fuentes, Cristóbal; Solari, Sandra; Martínez-Aguayo, Alejandro; García, Hernán; Carvajal, Cristian; Fardella, Carlos (Oxford University Press, 2018-09)
    Context Classical apparent mineralocorticoid excess (AME) is a rare recessive disorder, caused by severe 11β-hydroxysteroid dehydrogenase type 2 enzyme (11β-HSD2) deficiency. AME manifests as low-renin pediatric hypertension, ...
  • Calderón, Cristian; Contreras, Renato; Campodónico, Paola (Elsevier B.V., 2019-06)
    In this work, the influence of the C12-, C14-, and C16-alkyl chain derivatives of 1-alkyl-3-methyl-imidazole tetrafluoroborate over the hydrolisis of p-nitrophenyl trimethylacetate catalyzed by α-chymotrypsin was studied ...

View more