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Dirección de Investigación

Dirección de Investigación

 

Artículos, documentos de trabajo y otros documentos de investigación / Articles, working papers and other research papers

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  • Soto Simeone, Aracely Monserrat (Universidad del Desarrollo. Facultad de Economía y Negocios, 2021)
    This doctoral thesis builds on social identity theory to examine (i) how and why firm founders develop different social identity types; and (ii) how identification with social groups shapes founders’ entrepreneurial ...
  • Blanco, Alejandro; Morales, Fernanda; Marcelain, Katherine; Harismendy, Olivier; Sjöberg, Marcela; Armisen, Ricardo; de Santiago, Pamela (Elsevier Inc., 2020)
    Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) ...
  • Sánchez, Lucía; Labra, Andrés; Schiappacasse, Giancarlo (Soc. Argentina de Radiología, 2019)
    El colangiocarcinoma (CC) es el segundo tumor primario maligno más frecuente del hígado. La mayor incidencia se registra en Asia y su pronóstico es poco alentador. La resección quirúrgica del tumor es el único tratamiento ...
  • Sagredo, Eduardo; Sagredo, Alfredo; Blanco, Alejandro; Rojas, Pamela; Rivas, Solange; Assar, Rodrigo; Pérez, Paola; Marcelain, Katherine; Armisen, Ricardo (Elsevier B.V., 2020)
    RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
  • Pinto, Mauricio; Córdova-Delgado, Miguel; Retamal, Ignacio; Muñoz-Medel, Matías; Bravo, Loreto; Durán, Doris; Villanueva, Francisco; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Érica, Koch; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Garrido, Marcelo (MDPI, Basel Sz., 2020)
    Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
  • Capelli, Claudio; Sepúlveda, Hugo; Rivas, Solange; Víctor, Paola; Urzúa, Ulises; Donoso, Gerardo; Sagredo, Eduardo; Carrero, David; Casanova-Ortiz, Emmanuel; Sagredo, Alfredo; González, Marisel; Manterola, Marcia; Nardocci, Gino; Armisen, Ricardo; Montecino, Martín; Marcelain, Katherine (Elsevier Ltd., 2020)
    Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
  • Meneses-Salas, Elsa; Garcia-Forn, Marta; Castany-Pladevall, Carla; Lu, Albert; Fajardo, Alba; José, Jaimy; Wahba, Mohamed; Bosch, Marta; Pol, Albert; Tebar, Francesc; Klein, Andrés; Zanlungo, Silvana; Pérez-Navarro, Esther; Grewal, Thomas; Enrich, Carlos; Rentero, Carles (Elsevier Inc./ American Society for Investigative Pathology, 2020)
    Niemann-Pick type C disease (NP-C) is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NP-C disease primarily affects the brain, causing neuronal ...
  • Esteves Ribeiro, Grazielle (Universidad del Desarrollo. Facultad de Medicina, 2020)
    Hantaviruses are important human pathogens that cause a severe zoonotic disease called hantavirus cardiopulmonary syndrome (HCPS), presenting a case fatality rate up to 40%. Clinical course of HCPS may present as a mild ...
  • Contreras, Pablo; Tapia, Pablo; González-Hodar, Lila; Peluso, Ivana; Soldati, Chiara; Napoiotano, Gennaro; Matarese, María; Las Heras, Macarena; Valls, Cristian; Martínez, Alexis; Balboa, Elisa; Castro, Juan; Nancy, Leal; Platt, Frances; Sobota, Andrzej; Winter, Dominic; Klein, Andrés; Medina, Diego; Ballabio, Andrea; Alvarez, Alejandra; Zanlungo, Silvana (Cell Press, 2020)
    The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates ...
  • Barrera González, Matías; Rodríguez-Oroz, Delia; Alcalá-Reygosa, Jesús; Campos, Néstor (2020)
    Despite the wide diversity of landforms, there are only a few geomorphological maps of the Chilean Central Andes. In this study, we present a detailed geomorphological map on a 1:50.000 scale for the Diguillín Valley (Ñuble ...
  • Vera-Villarroel, Pablo; Urzúa, Alfonso; Jaime, Daniela; Contreras, Daniela; Zych, Izabela; Celis-Atenas, Karem; Silva, Jaime R.; Lillo, Sebastian (2019)
    We evaluated the factor structure, reliability, and discriminative capacity of the Positive and Negative Affect Schedule (PANAS) questionnaire in four different samples: two general adult populations (N = 1,548, N = 964), ...
  • Díaz, Diego A.; Jiménez, Ana María; Larroulet, Cristián (2019)
    Going from a neighbourhood-based to a choice-based system of school selection can have positive effects on enrolment in higher achievement schools, increasing average student achievement. We develop an Agent-Based model ...
  • Bosch, Paul; Rodríguez, José Manuel; Rosario, Omar; Sigarreta, José María (2019)
    Using the symmetry property of the inverse degree index, in this paper, we obtain several mathematical relations of the inverse degree polynomial, and we show that some properties of graphs, such as the cardinality of the ...
  • Villegas Mateos, Allan Oswaldo; Amorós, José Ernesto (2019)
    Purpose – The entrepreneurial ecosystem approach tries to understand the mechanisms underlying new business creation and helps develop tools, governmental policies and support systems that enhance the outcomes of ...
  • Parada‑Contzen, Marcela; Vásquez Lavín, Felipe (2019)
    We perform a cost–beneft analysis on the introduction of monetary incentives for living kidney donations by estimating the compensation that would make an individual indiferent between donating and not donating a kidney ...
  • Schmidt, Carlos; Reyes, Gabriel; Barrientos, Mauricio; Langer, Álvaro I.; Sackur, Jérôme (2019)
    In the last decade of research on metacognition, the literature has been focused on understanding its mechanism, function and scope; however, little is known about whether metacognitive capacity can be trained. The specificity ...
  • Ferres, Leo; Fuentes-Sepúlveda, José; Gagie, Travis; He, Meng; Navarro, Gonzalo (2019)
    There are many representations of planar graphs, but few are as elegant as Turán’s (1984): it is simple and practical, uses only 4 bits per edge, can handle self-loops and multi-edges, and can store any specified embedding. ...
  • Coo, Soledad; García, María Ignacia; Awad, Natalia; Rowe, Heather; Fisher, Jane (2019)
    Objective: The aim of this study was to culturally adapt What Were We Thinking (WWWT), an Australian psychoeducational intervention to prevent symptoms of depression and anxiety among firsttime mothers, to be used in the ...
  • Guzmán, Javier; Alfaro, Jaime; Varela, Jorge J. (2019)
    This study aims to contribute to the understanding of life satisfaction in Chilean adolescents, integrating dimensions regarding the relationship between the individual and their community environment. Specifically, this ...
  • Mella, Eduardo; Rodríguez, M. Andrea; Bravo, Loreto; Gatica, Diego (2019)
    Query processing is an important challenge for spatial databases due to the use of complex data types that represent spatial attributes. In particular, due to the cost of spatial joins, several optimization algorithms based ...

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