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Dirección de Investigación

 

Artículos, documentos de trabajo y otros documentos de investigación / Articles, working papers and other research papers

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  • Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer; Klein, Andrés; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony; Addo, Marylyn; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp; Lang, Karl (Frontiers Media SA, 2021)
    Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, ...
  • Figueroa, Oriana (Universidad del Desarrollo. Facultad de Gobierno, 2021-03-11)
    El presente trabajo buscó comprender las estrategias reproductivas en los hombres, integrando aspectos biológicos, psicológicos y conductuales en un marco evolutivo. Se presentan dos manuscritos publicados: “The Male Warrior ...
  • Suárez Delucchi, Nicolás; Fossa, Pablo (2020)
    This article develops a theoretical articulation between Freud’s conceptions about the functioning of the unconscious system and the phenomenon described by Vygotsky as “inner language.” We describe Vygotsky’s theoretical ...
  • Fossa, Pablo; Molina, María Elisa; Jacob, Lina; Gube, Jan; Sawitzk, Franziska (2020)
    This article develops a theoretical model about the trajectories and transitions of thought from a perspective of semiotic cultural psychology. An integration between the inner speech theory, concept formation, and ...
  • Madrigal Pérez, Raymond; Fossa, Pablo (2020)
    En el presente trabajo se discuten las implicaciones que la subjetividad, definida por González Rey como cultural-histórica, tienen para el proceso de enseñanza-aprendizaje que tiene como escenario la escuela. Históricamente ...
  • Madrigal Pérez, Raymond; Fossa, Pablo; Barros, Matías (2020)
    In the theoretical thinking of González Rey, the acknowledge of the generating character of emotions and their infinite unfolding associated with symbolic productions, which are not of the order of meaning, has represented ...
  • Barros, Matías; Fossa, Pablo; Luca Picione, Raffaele de; Molina, María Elisa (2020)
    This article presents the results of a theoretical investigation that aimed to develop a comprehensive model regarding the phenomenon of imagination and private speech as liminal experiences of consciousness. A theoretical ...
  • Fossa, Pablo; Molina, María Elisa; Puerta, Sofía de la; Barr, Michelle (2020)
    The purpose of this article was exploring the role of discursive and non-discursive symbolization - specifically gestures - in the negotiation of differences in couples´ interactions. Five married heterosexual couples ...
  • Soto Simeone, Aracely Monserrat (Universidad del Desarrollo. Facultad de Economía y Negocios, 2021)
    This doctoral thesis builds on social identity theory to examine (i) how and why firm founders develop different social identity types; and (ii) how identification with social groups shapes founders’ entrepreneurial ...
  • Blanco, Alejandro; Morales, Fernanda; Marcelain, Katherine; Harismendy, Olivier; Sjöberg, Marcela; Armisen, Ricardo; de Santiago, Pamela (Elsevier Inc., 2020)
    Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) ...
  • Sánchez, Lucía; Labra, Andrés; Schiappacasse, Giancarlo (Soc. Argentina de Radiología, 2019)
    El colangiocarcinoma (CC) es el segundo tumor primario maligno más frecuente del hígado. La mayor incidencia se registra en Asia y su pronóstico es poco alentador. La resección quirúrgica del tumor es el único tratamiento ...
  • Sagredo, Eduardo; Sagredo, Alfredo; Blanco, Alejandro; Rojas, Pamela; Rivas, Solange; Assar, Rodrigo; Pérez, Paola; Marcelain, Katherine; Armisen, Ricardo (Elsevier B.V., 2020)
    RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
  • Pinto, Mauricio; Córdova-Delgado, Miguel; Retamal, Ignacio; Muñoz-Medel, Matías; Bravo, Loreto; Durán, Doris; Villanueva, Francisco; Sánchez, César; Acevedo, Francisco; Mondaca, Sebastián; Érica, Koch; Ibáñez, Carolina; Galindo, Héctor; Madrid, Jorge; Nervi, Bruno; Peña, José; Torres, Javiera; Garrido, Marcelo (MDPI, Basel Sz., 2020)
    Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require ...
  • Capelli, Claudio; Sepúlveda, Hugo; Rivas, Solange; Víctor, Paola; Urzúa, Ulises; Donoso, Gerardo; Sagredo, Eduardo; Carrero, David; Casanova-Ortiz, Emmanuel; Sagredo, Alfredo; González, Marisel; Manterola, Marcia; Nardocci, Gino; Armisen, Ricardo; Montecino, Martín; Marcelain, Katherine (Elsevier Ltd., 2020)
    Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
  • Meneses-Salas, Elsa; Garcia-Forn, Marta; Castany-Pladevall, Carla; Lu, Albert; Fajardo, Alba; José, Jaimy; Wahba, Mohamed; Bosch, Marta; Pol, Albert; Tebar, Francesc; Klein, Andrés; Zanlungo, Silvana; Pérez-Navarro, Esther; Grewal, Thomas; Enrich, Carlos; Rentero, Carles (Elsevier Inc./ American Society for Investigative Pathology, 2020)
    Niemann-Pick type C disease (NP-C) is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NP-C disease primarily affects the brain, causing neuronal ...
  • Esteves Ribeiro, Grazielle (Universidad del Desarrollo. Facultad de Medicina, 2020)
    Hantaviruses are important human pathogens that cause a severe zoonotic disease called hantavirus cardiopulmonary syndrome (HCPS), presenting a case fatality rate up to 40%. Clinical course of HCPS may present as a mild ...
  • Contreras, Pablo; Tapia, Pablo; González-Hodar, Lila; Peluso, Ivana; Soldati, Chiara; Napoiotano, Gennaro; Matarese, María; Las Heras, Macarena; Valls, Cristian; Martínez, Alexis; Balboa, Elisa; Castro, Juan; Nancy, Leal; Platt, Frances; Sobota, Andrzej; Winter, Dominic; Klein, Andrés; Medina, Diego; Ballabio, Andrea; Alvarez, Alejandra; Zanlungo, Silvana (Cell Press, 2020)
    The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates ...
  • Barrera González, Matías; Rodríguez-Oroz, Delia; Alcalá-Reygosa, Jesús; Campos, Néstor (2020)
    Despite the wide diversity of landforms, there are only a few geomorphological maps of the Chilean Central Andes. In this study, we present a detailed geomorphological map on a 1:50.000 scale for the Diguillín Valley (Ñuble ...
  • Vera-Villarroel, Pablo; Urzúa, Alfonso; Jaime, Daniela; Contreras, Daniela; Zych, Izabela; Celis-Atenas, Karem; Silva, Jaime R.; Lillo, Sebastian (2019)
    We evaluated the factor structure, reliability, and discriminative capacity of the Positive and Negative Affect Schedule (PANAS) questionnaire in four different samples: two general adult populations (N = 1,548, N = 964), ...
  • Díaz, Diego A.; Jiménez, Ana María; Larroulet, Cristián (2019)
    Going from a neighbourhood-based to a choice-based system of school selection can have positive effects on enrolment in higher achievement schools, increasing average student achievement. We develop an Agent-Based model ...

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