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Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder

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dc.contributor.author Zamorano, Francisco
dc.contributor.author Aboitiz, Francisco
dc.contributor.author Carrasco, Ximena
dc.contributor.author López, Vladimir
dc.contributor.author Hurtado, José M.
dc.contributor.author Stecher, Ximena
dc.contributor.author Larrain, Josefina
dc.contributor.author Kausel, Leonie
dc.contributor.author Billeke, Pablo
dc.date.accessioned 2018-02-23T15:50:16Z
dc.date.available 2018-02-23T15:50:16Z
dc.date.issued 2017
dc.identifier.citation Scientific Reports, Volumen: 7 Número de artículo: 7181
dc.identifier.uri http://hdl.handle.net/11447/1997
dc.identifier.uri http://dx.doi.org/10.1038/s41598-017-07681-z
dc.description.abstract Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a "congruent condition" and an "incongruent condition". The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT.
dc.language.iso en_US
dc.subject ADHD
dc.subject Bipolar Disorder
dc.subject Executive functions
dc.subject Response-inhibition
dc.subject Psychiatric-disorders
dc.subject Behavioral-inhibition
dc.subject Cognitive control
dc.subject Orbitofrontal cortex
dc.subject Hyperactivity Disorder
dc.subject Deficit
dc.subject Multisource interference task
dc.title Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
dc.type Artículo


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