Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder

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dc.contributor.authorZamorano, Francisco
dc.contributor.authorAboitiz, Francisco
dc.contributor.authorCarrasco, Ximena
dc.contributor.authorLópez, Vladimir
dc.contributor.authorHurtado, José M.
dc.contributor.authorStecher, Ximena
dc.contributor.authorLarraín, Josefina
dc.contributor.authorKausel, Leonie
dc.contributor.authorBilleke, Pablo
dc.date.accessioned2018-02-23T15:50:16Z
dc.date.available2018-02-23T15:50:16Z
dc.date.issued2017
dc.description.abstractAttention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a "congruent condition" and an "incongruent condition". The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT.
dc.identifier.citationZamorano F, Billeke P, Kausel L, Larrain J, Stecher X, Hurtado JM, López V, Carrasco X, Aboitiz F. Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder. Sci Rep. 2017 Aug 3;7(1):7181
dc.identifier.urihttp://hdl.handle.net/11447/1997
dc.identifier.urihttp://dx.doi.org/10.1038/s41598-017-07681-z
dc.language.isoen_US
dc.subjectADHD
dc.subjectBipolar Disorder
dc.subjectExecutive functions
dc.subjectResponse-inhibition
dc.subjectPsychiatric-disorders
dc.subjectBehavioral-inhibition
dc.subjectCognitive control
dc.subjectOrbitofrontal cortex
dc.subjectHyperactivity Disorder
dc.subjectDeficit
dc.subjectMultisource interference task
dc.titleLateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
dc.typeArtículo

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