Epidemiology of candidemia in Latin America: a laboratory-based survey

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dc.contributor.authorNucci, Marcio
dc.contributor.authorQueiroz-Telles, Flavio
dc.contributor.authorAlvarado-Matute, Tito
dc.contributor.authorTiraboschi, Iris
dc.contributor.authorCortes, Jorge
dc.contributor.authorZurita, Jeannete
dc.contributor.authorGuzman-Blanco, Manuel
dc.contributor.authorSantolaya, Maria
dc.contributor.authorThompson, Luis
dc.contributor.authorSifuentes-Osornio, Jose
dc.contributor.authorEchevarria, Juan
dc.contributor.authorColombo, Arnaldo
dc.date.accessioned2017-04-17T14:10:49Z
dc.date.available2017-04-17T14:10:49Z
dc.date.issued2013
dc.description.abstractBACKGROUND: The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America. METHODS: We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized. RESULTS: Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%. CONCLUSIONS: This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.
dc.format.extent7
dc.identifier.citationPLoS One, 2013; 8(3): e59373
dc.identifier.urihttp://hdl.handle.net/11447/1154
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0059373
dc.language.isoen_US
dc.publisherPLoS
dc.subjectCandida
dc.subjectCandidemia/drug therapy
dc.subjectCandidemia/epidemiology
dc.subjectFluconazole/therapeutic use
dc.titleEpidemiology of candidemia in Latin America: a laboratory-based survey
dc.typeArtículo

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