Epidemiology of candidemia in Latin America: a laboratory-based survey
Date
2013
Type:
Artículo
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7
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ORCID:
Journal Title
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Volume Title
Publisher
PLoS
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Abstract
BACKGROUND:
The epidemiology of candidemia varies depending on the geographic region. Little is known about the epidemiology of candidemia in Latin America.
METHODS:
We conducted a 24-month laboratory-based survey of candidemia in 20 centers of seven Latin American countries. Incidence rates were calculated and the epidemiology of candidemia was characterized.
RESULTS:
Among 672 episodes of candidemia, 297 (44.2%) occurred in children (23.7% younger than 1 year), 36.2% in adults between 19 and 60 years old and 19.6% in elderly patients. The overall incidence was 1.18 cases per 1,000 admissions, and varied across countries, with the highest incidence in Colombia and the lowest in Chile. Candida albicans (37.6%), C. parapsilosis (26.5%) and C. tropicalis (17.6%) were the leading agents, with great variability in species distribution in the different countries. Most isolates were highly susceptible to fluconazole, voriconazole, amphotericin B and anidulafungin. Fluconazole was the most frequent agent used as primary treatment (65.8%), and the overall 30-day survival was 59.3%.
CONCLUSIONS:
This first large epidemiologic study of candidemia in Latin America showed a high incidence of candidemia, high percentage of children, typical species distribution, with C. albicans, C. parapsilosis and C. tropicalis accounting for the majority of episodes, and low resistance rates.
Description
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Citation
PLoS One, 2013; 8(3): e59373
Keywords
Candida, Candidemia/drug therapy, Candidemia/epidemiology, Fluconazole/therapeutic use