Electrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines
Date
2022
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Article
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Abstract
Abstract: Potential drug-eluting scaffolds of electrospun poly(acrylic acid-co-styrene sulfonate) P(AAco-SS) in clonogenic assays using tumorigenic gastric and ovarian cancer cells were tested in vitro. Electrospun polymer nanofiber (EPnF) meshes of PAA and PSSNa homo- and P(AA-co-SS) copolymer composed of 30:70, 50:50, 70:30 acrylic acid (AA) and sodium 4-styrene sulfonate (SSNa) units were performed by electrospinning (ES). The synthesis, structural and morphological characterization of
all EPnF meshes were analyzed by optical and electron microscopy (SEM-EDS), infrared spectroscopy (FTIR), contact angle, and X-ray diffraction (XRD) measurements. This study shows that different ratio
of AA and SSNa of monomers in P(AA-co-SS) EPnF play a crucial role in clonogenic in vitro assays. We found that 50:50 P(AA-co-SS) EPnF mesh loaded with antineoplastic drugs can be an excellent suppressor of growth-independent anchored capacities in vitro assays and a good subcutaneous drug delivery system for chemotherapeutic medication in vivo model for surgical resection procedures in cancer research.
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Citation
Neira-Carrillo, A.; Zárate, I.A.; Nieto, E.; Butto-Miranda, N.; Lobos-González, L.; Del Campo-Smith, M.; Palacio, D.A.; Urbano, B.F. Electrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines. Nanomaterials 2022, 12, 3903. https://doi.org/10.3390/ nano12213903
Keywords
Electrospun fibers, Electrospinning, Poly(acrylic acid-co-styrene sulfonate), Gastric and breast cancer cells, Clonogenic assay, Polymers