Electrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines

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dc.contributor.authorNeira, Andrónico
dc.contributor.authorZárate, Ignacio
dc.contributor.authorNieto, Eddie
dc.contributor.authorButto, Nicole
dc.contributor.authorLobos-González, Lorena
dc.contributor.authorDel Campo, Matías
dc.contributor.authorPalacio, Daniel
dc.contributor.authorUrbano, Bruno
dc.date.accessioned2022-11-17T15:12:36Z
dc.date.available2022-11-17T15:12:36Z
dc.date.issued2022
dc.description.abstractAbstract: Potential drug-eluting scaffolds of electrospun poly(acrylic acid-co-styrene sulfonate) P(AAco-SS) in clonogenic assays using tumorigenic gastric and ovarian cancer cells were tested in vitro. Electrospun polymer nanofiber (EPnF) meshes of PAA and PSSNa homo- and P(AA-co-SS) copolymer composed of 30:70, 50:50, 70:30 acrylic acid (AA) and sodium 4-styrene sulfonate (SSNa) units were performed by electrospinning (ES). The synthesis, structural and morphological characterization of all EPnF meshes were analyzed by optical and electron microscopy (SEM-EDS), infrared spectroscopy (FTIR), contact angle, and X-ray diffraction (XRD) measurements. This study shows that different ratio of AA and SSNa of monomers in P(AA-co-SS) EPnF play a crucial role in clonogenic in vitro assays. We found that 50:50 P(AA-co-SS) EPnF mesh loaded with antineoplastic drugs can be an excellent suppressor of growth-independent anchored capacities in vitro assays and a good subcutaneous drug delivery system for chemotherapeutic medication in vivo model for surgical resection procedures in cancer research.es
dc.description.versionVersión publicadaes
dc.identifier.citationNeira-Carrillo, A.; Zárate, I.A.; Nieto, E.; Butto-Miranda, N.; Lobos-González, L.; Del Campo-Smith, M.; Palacio, D.A.; Urbano, B.F. Electrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lines. Nanomaterials 2022, 12, 3903. https://doi.org/10.3390/ nano12213903es
dc.identifier.urihttps://doi.org/10.3390/nano12213903es
dc.identifier.urihttp://hdl.handle.net/11447/6683
dc.language.isoenes
dc.subjectElectrospun fiberses
dc.subjectElectrospinninges
dc.subjectPoly(acrylic acid-co-styrene sulfonate)es
dc.subjectGastric and breast cancer cellses
dc.subjectClonogenic assayes
dc.subjectPolymerses
dc.titleElectrospun Poly(acrylic acid-co-4-styrene sulfonate) as Potential Drug-Eluting Scaffolds for Targeted Chemotherapeutic Delivery Systems on Gastric (AGS) and Breast (MDA-Mb-231) Cancer Cell Lineses
dc.typeArticlees
dcterms.sourceNanomaterialses

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