Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells

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Amitriptyline down-regulates coenzyme Q10biosynthesis in lung cancer cells.pdf (687.32 KB)

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2017

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Article

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Artículos Ciencias de la Salud

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170

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1
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http://dx.doi.org/10.1016/j.ejphar.2017.01.017. Epub 2017 Jan 15.
 http://hdl.handle.net/11447/5472

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Abstract

Amitriptyline, a tricyclic antidepressant, has been proposed as an antitumoral drug in oxidative therapy. Its proapoptotic effects, mediated by high reactive oxygen species generation, have been alrea...

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Ortiz T, Villanueva-Paz M, Díaz-Parrado E, Illanes M, Fernández-Rodríguez A, Sánchez-Alcázar JA, de Miguel M. Amitriptyline down-regulates coenzyme Q10 biosynthesis in lung cancer cells. Eur J Pharmacol. 2017 Feb 15;797:75-82.

Keywords

Amitriptyline , Coenzyme Q10 , Oxidative stress , Antioxidants , Oxidative therapy

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