Pharmacological treatment of bipolar depression
Date
2014
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Article
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Abstract
Bipolar depression remains a major challenge for psychiatric therapeutics. It is associated with disability and excess mortality, and accounts for three-quarters of the time spent in morbid states by treated patients with bipolar disorder. Major limitations of research on the treatment of depression in bipolar disorder include a paucity of short-term and lack of long-term trials, probably reflecting concern about inducing mania. In addition, polytherapy with multiple drugs appears to be widespread, but it is virtually untested for efficacy and safety. Here, we summarise the evidence concerning efficacy of treatment of bipolar depression with antidepressants, mood- stabilising anticonvulsants, lithium and second-generation antipsychotics.
Description
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Citation
Advances in psychiatric treatment, 2014, 20: 193–201
Keywords
Bipolar depression, Pharmacological treatment, Antidepressants, Anticonvulsants, Lithium, Antipsychotics