Bilateral lung disease, extensive and diffuse. Diagnosis of pulmonary alveolar proteinosis by bronchoscopic cryobiopsy
Date
2017
Type:
Artículo
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3
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ORCID:
Journal Title
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Volume Title
Publisher
Elsevier
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Abstract
Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the intra-alveolar accumulation of a
proteinaceous phospholipid-laden material called surfactant. Clinically, this disease should be suspected with
respiratory failure in association with a crazy paving pattern on high-resolution chest computed tomography. We
report a 24-year-old gentleman who was referred to us for a history of respiratory failure, treatment with invasive
ventilation and tracheostomy. His blood exams and biochemistry were normal. His infectious and
rheumatological panel was negative for a secondary disease. A flexible bronchoscopy with a transbronchial
biopsy through a CryoProbe was performed. An anatomopathological analysis was periodic acid-Schiff positive
for PAP. A CryoProbe is a recently developed diagnostic tool that improves the diagnostic yield in diffuse lung
diseases compared to bronchoscopy with transbronchial biopsy. This method should be considered for patients
with diffuse lung disease and PAP.
Description
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Citation
Gando S, Duré R, Violi D, Vazquez B, Labarca G, Fernandez-Bussy S. Bilateral lung disease, extensive and diffuse. Diagnosis of pulmonary alveolar proteinosis by bronchoscopic cryobiopsy. Respir Med Case Rep. 2017 Sep 28;22:260-262. doi: 10.1016/j.rmcr.2017.09.010
Keywords
Pulmonary alveolar proteinosis, CryoProbe, Bronchoscopy