Estimulación cerebral profunda en enfermedad de Parkinson
Date
2018
Type:
Article
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Abstract
Background: Deep brain stimulation is an essential therapeutic tool in Parkinson´s disease. Aim: To assess the results of a series of patients with Parkinson’s
disease treated with micro-electrode guided subthalamic nucleus stimulation.
Material and Methods: Twenty patients with idiopathic Parkinson’s disease
were studied (10 males). Three months after surgery, we analyzed the change in
motor disturbances, medication need to control symptoms and quality of life. Results: We observed a significant improvement in all the assessed variables. Motor
involvement determined as OFF hours and expressed as percentage of the day
changed from 30 ± 15 to 10 ± 7% in the preoperative and postoperative periods,
respectively. ON hours without dyskinesia changed from 17 ± 16 to 78 ± 21%.
ON hours with dyskinesia changed from 53 ± 23 to 12 ± 15%. Medication need
changed from 1,505 ± 499 to 1,214 ± 528 levodopa equivalents. Parkinson’s
Disease Questionnaire 39 score changed from 62.9 ± 22.7 to 34.3 ± 18.5. During
the 5-year follow-up a continuous improvement of symptoms was observed.
Conclusions: Micro-electrode guided subthalamic nucleus functional surgery in
patients with Parkinson’s disease has good immediate and late results
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Citation
Kunstmann Carolina, Valdivia Felipe, De Marinis Alejandro, Ayach Fredy, Montes José Miguel, Chana-Cuevas Pedro. Estimulación cerebral profunda en enfermedad de Parkinson. Rev. méd. Chile [Internet]. 2018 Mayo [citado 2022 Mayo 23] ; 146( 5 ): 562-569. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872018000500562&lng=es. http://dx.doi.org/10.4067/s0034-98872018000500562.
Keywords
Deep Brain Stimulation, Parkinson Disease, Subthalamic Nucleus