NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease

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dc.contributor.authorMartinez-Fong, Daniel
dc.contributor.authorBannon, Michael J.
dc.contributor.authorTrudeau, Louis-Eric
dc.contributor.authorGonzalez-Barrios, Juan A.
dc.contributor.authorArango-Rodriguez, Martha L.
dc.contributor.authorHernandez-Chan, Nancy G.
dc.contributor.authorReyes-Corona, David
dc.contributor.authorArmendáriz-Borunda, Juan
dc.contributor.authorNavarro-Quiroga, Ivan
dc.date.accessioned2021-10-04T17:42:12Z
dc.date.available2021-10-04T17:42:12Z
dc.date.issued2012
dc.description.abstractNanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson's disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a “Trojan horse” synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson's disease.es
dc.identifier.citationNanomedicine: Nanotechnology, Biology, and Medicine , 2012, 8: 1052–1069es
dc.identifier.urihttp://dx.doi.org/10.1016/j.nano.2012.02.009es
dc.identifier.urihttp://hdl.handle.net/11447/4785
dc.language.isoenes
dc.subjectNeurorestorationes
dc.subjectNeuroprotectiones
dc.subjectNeurodegenerationes
dc.subjectRegenerationes
dc.subjectSurvivales
dc.titleNTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's diseasees
dc.typeArticlees

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