NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease
Date
2012
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Article
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Abstract
Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy to stop and reverse neurodegeneration in Parkinson's disease. Because of improved transfection ability, synthetic nanocarriers have become candidates for neurotrophic therapy. Neurotensin (NTS)-polyplex is a “Trojan horse” synthetic nanocarrier system that enters dopaminergic neurons through NTS receptor internalization to deliver a genetic cargo. The success of preclinical studies with different neurotrophic genes supports the possibility of using NTS-polyplex in nanomedicine. In this review, we describe the mechanism of NTS-polyplex transfection. We discuss the concept that an effective neurotrophic therapy requires a simultaneous effect on the axon terminals and soma of the remaining dopaminergic neurons. We also discuss the future of this strategy for the treatment of Parkinson's disease.
Description
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Citation
Nanomedicine: Nanotechnology, Biology, and Medicine , 2012, 8: 1052–1069
Keywords
Neurorestoration, Neuroprotection, Neurodegeneration, Regeneration, Survival