Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.

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dc.contributor.authorSoto, Jorge
dc.contributor.authorDiaz-Dinamarca, Diego
dc.contributor.authorSoto, Daniel
dc.contributor.authorBarrientos, Magaly
dc.contributor.authorCarrión, Flavio
dc.contributor.authorKalergis, Alexis
dc.contributor.authorVásquez, Abel
dc.date.accessioned2020-04-08T15:37:38Z
dc.date.available2020-04-08T15:37:38Z
dc.date.issued2019
dc.description.abstractGroup B Streptococcus (GBS) represents one of the most common causes of bacterial infection in neonates; it is also associated with premature childbirth and stillbirth. A vaccine against GBS is needed, but no approved vaccines are yet available. The Surface Immunogenic Protein (SIP) of GBS is conserved in all serotypes and had been reported to be a good vaccine prototype in a mouse model of GBS infection. Also, we have previously shown that both subcutaneous and oral immunization with rSIP can induce an efficient immune response that decreases GBS vaginal colonization in mice. In this study, we show that a vaccine based on a mixture of rSIP and AbISCO-100 adjuvant reduces GBS vaginal colonization in mice and induces antibodies with opsonophagocytic activities. Moreover, the passive transfer of sera and total T-cells from mice immunized with rSIP mixed with AbISCO-100 to unvaccinated mice decreases vaginal GBS colonization in an infected mouse. This is the first report of cellular immunity associated with rSIP-based vaccine testing in a mouse model of GBS infection.
dc.identifier.citationMol Immunol. 2019 Jul;111:198-204. doi: 10.1016/j.molimm.2019.04.025
dc.identifier.urihttp://hdl.handle.net/11447/3218
dc.identifier.urihttps://doi.org/10.1016/j.molimm.2019.04.025
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectAbISCO-100
dc.subjectGroup B Streptococcus
dc.subjectCellular immunity
dc.titleCellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization.
dc.typePreprint

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