A multispecies outbreak of carbapenem-resistant bacteria harboring the blaKPC gene in a non-classical transposon element

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dc.contributor.authorWozniak, Aniela
dc.contributor.authorFigueroa, Cristian
dc.contributor.authorMoya-Flores, Francisco
dc.contributor.authorGuggiana, Piero
dc.contributor.authorCastillo, Claudia
dc.contributor.authorRivas, Lina
dc.contributor.authorMunita, José
dc.contributor.authorGarcía, Patricia C.
dc.date.accessioned2022-01-11T18:20:18Z
dc.date.available2022-01-11T18:20:18Z
dc.date.issued2021
dc.description.abstractKlebsiella pneumoniae is the most frequent KPC-producing bacteria. The blaKPC gene is frequently embedded in Tn4401 transposon, and less frequently in non-Tn4401 elements (NTEKPC) variants I-III. The first case of KPC in the UC-CHRISTUS Clinical Hospital was detected in Pseudomonas aeruginosa. Soon after this event, KPC was detected in 2 additional Pseudomonas aeruginosa, 3 Escherichia coli, 3 Enterobacter cloacae, 3 Klebsiella pneumoniae, and 1 Citrobacter freundii, isolated from 6 different patients. We aimed to elucidate the possible mechanisms of genetic transfer and dissemination of the blaKPC gene among isolates of this multispecies outbreak. A molecular epidemiology analysis of the above mentioned clinical isolates (n = 13) through Multi-Locus Sequence Typing, plasmid analysis, Pulsed-Field Gel-Electrophoresis, and Whole-genome sequencing (WGS) was performed.es
dc.description.versionVersión publicada
dc.identifier.citationWozniak, A., Figueroa, C., Moya-Flores, F. et al. A multispecies outbreak of carbapenem-resistant bacteria harboring the blaKPC gene in a non-classical transposon element. BMC Microbiol 21, 107 (2021). https://doi.org/10.1186/s12866-021-02169-3es
dc.identifier.urihttps://doi.org/10.1186/s12866-021-02169-3es
dc.identifier.urihttp://hdl.handle.net/11447/5429
dc.language.isoeses
dc.subjectKPC Carbapenemasees
dc.subjectCarbapenem resistant Enterobacteriaceaees
dc.subjectMultispecies outbreakes
dc.subjectHorizontal gene transferes
dc.titleA multispecies outbreak of carbapenem-resistant bacteria harboring the blaKPC gene in a non-classical transposon elementes
dc.typeArticlees
dcterms.sourceBMC Microbiologyes

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