Modified natural cycle IVF versus conventional stimulation in advanced-age Bologna poor responders

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dc.contributor.authorPanagiotis, Drakopoulos
dc.contributor.authorRomito, Alessia
dc.contributor.authorErrázuriz, Joaquín
dc.contributor.authorSantos-Ribeiro, Samuel
dc.contributor.authorPopovic-Todorovic, Biljana
dc.contributor.authorRacca, Annalisa
dc.contributor.authorTournaye, Herman
dc.contributor.authorVos, Michel De
dc.contributor.authorBlockeel, Christophe
dc.date.accessioned2022-07-12T21:51:13Z
dc.date.available2022-07-12T21:51:13Z
dc.date.issued2019
dc.description.abstractResearch question: Do ongoing pregnancy rates (OPR) differ between modified natural cycle IVF (MNC-IVF) and conventional high-dose ovarian stimulation (HDOS) in advanced-age Bologna poor responders? Design: This was a retrospective cohort study including patients with poor ovarian response (POR) attending a tertiary referral university hospital from 1 January 2011 to 1 March 2017. All women who fulfilled the Bologna criteria for POR and aged ≥40 years who underwent their first intracytoplasmic sperm injection (ICSI) cycle in the study centre were included. Results: In total, 476 advanced-age Bologna poor responder patients were included in the study: 189 in the MNC-IVF group and 287 in the HDOS group. OPR per patient were significantly lower in the MNC-IVF group (5/189, 2.6%) compared with the HDOS group (29/287, 10.1%) (P = 0.002). However, after adjustment for relevant confounders (number of oocytes and presence of at least one top-quality embryo), the multivariate logistic regression analysis showed that the type of treatment strategy (HDOS versus MNC-IVF) was not significantly associated with OPR (odds ratio 2.56, 95% confidence interval 0.9-7.6). Conclusions: In advanced-age Bologna poor responders, MNC-IVF, which is a more patient-friendly approach, could be a reasonable alternative in this difficult-to-treat group of women.es
dc.description.versionVersión Publicadaes
dc.identifier.citationDrakopoulos P, Romito A, Errázuriz J, Santos-Ribeiro S, Popovic-Todorovic B, Racca A, Tournaye H, De Vos M, Blockeel C. Modified natural cycle IVF versus conventional stimulation in advanced-age Bologna poor responders. Reprod Biomed Online. 2019 Oct;39(4):698-703. doi: 10.1016/j.rbmo.2019.05.009.es
dc.identifier.urihttps://doi.org/10.1016/j.rbmo.2019.05.009es
dc.identifier.urihttp://hdl.handle.net/11447/6362
dc.language.isoenes
dc.subjectBologna criteriaes
dc.subjectIVFes
dc.subjectModified natural cyclees
dc.subjectOocyteses
dc.subjectPoor responderses
dc.titleModified natural cycle IVF versus conventional stimulation in advanced-age Bologna poor responderses
dc.typeArticlees
dcterms.sourceReproductive BioMedicine Onlinees

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