Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects

Simple item page
dc.contributor.authorCapponi, Valentina
dc.contributor.authorCarrasco, Carmen
dc.contributor.authorMacchiavello, Stefano
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCampino, Carmen
dc.contributor.authorCarvajal, Cristian
dc.contributor.authorGómez, Teresita
dc.contributor.authorWeiss, Cristian
dc.contributor.authorAedo, Igor
dc.contributor.authorVecchiola, Andrea
dc.contributor.authorAllende, Fidel
dc.contributor.authorSolari, Sandra
dc.contributor.authorFardella, Carlos
dc.contributor.authorBaudrand, René
dc.date.accessioned2022-05-23T20:59:22Z
dc.date.available2022-05-23T20:59:22Z
dc.date.issued2018
dc.description.abstractBACKGROUND: Cortisol dysregulation has a potential role in depression. AIM AND METHODS: We evaluated depressive symptoms using the Hamilton Rat- ing Scale for Depression in 48 primary care subjects without history of previous or current depression and its association with cortisol dysregulation (morning plasma cortisol, 24-hour urinary free cortisol and cortisol metabolites). Presence of metabolic syndrome and inflammatory parameters were also assessed. RESULTS: Hamilton Rating Scale for Depression correlated significantly with morning cortisol, but not with urinary free cortisol or metabolites. A significant increase in morning cortisol by Hamilton groups (asymptomatic ≤8; mild to moderate: 9–18; moderate to severe: ≥19) was observed even when adjusted by age/gender. We observed no association of depressive symptoms with metabolic or inflammatory parameters. CONCLUSIONS: Depressive symptoms in primary care subjects not consulting for their mood are associated with higher morning plasma cortisol, but not urinary cortisol or its metabolites. These observations suggest that systemic hypercorti- solism and related metabolic disorders are not observed in mild/initial states of depressive disorders.es
dc.description.versionVersión Publicadaes
dc.identifier.citationCapponi V, Carrasco C, Macchiavello S, Undurraga J, Campino C, Carvajal C, Gomez T, Weiss C, Aedo I, Vecchiola A, Allende F, Solari S, Fardella C, Baudrand R. Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects. Neuro Endocrinol Lett. 2018 Oct;39(4):288-293. PMID: 30531699.es
dc.identifier.urihttp://hdl.handle.net/11447/6125
dc.language.isoenes
dc.subjectDepressiones
dc.subjectMood disorderes
dc.subjectPituitary adrenal systemes
dc.subjectCortisoles
dc.subjectMetabolic syndromees
dc.titleDepressive symptoms are associated with higher morning plasma cortisol in primary care subjectses
dc.typeArticlees
dcterms.sourceNeuroendocrinology Letterses

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects.pdf
Size:
97.69 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services