Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects
Date
2018
Type:
Article
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Abstract
BACKGROUND: Cortisol dysregulation has a potential role in depression.
AIM AND METHODS: We evaluated depressive symptoms using the Hamilton Rat-
ing Scale for Depression in 48 primary care subjects without history of previous
or current depression and its association with cortisol dysregulation (morning
plasma cortisol, 24-hour urinary free cortisol and cortisol metabolites). Presence
of metabolic syndrome and inflammatory parameters were also assessed.
RESULTS: Hamilton Rating Scale for Depression correlated significantly with
morning cortisol, but not with urinary free cortisol or metabolites. A significant
increase in morning cortisol by Hamilton groups (asymptomatic ≤8; mild to
moderate: 9–18; moderate to severe: ≥19) was observed even when adjusted by
age/gender. We observed no association of depressive symptoms with metabolic
or inflammatory parameters.
CONCLUSIONS: Depressive symptoms in primary care subjects not consulting for
their mood are associated with higher morning plasma cortisol, but not urinary
cortisol or its metabolites. These observations suggest that systemic hypercorti-
solism and related metabolic disorders are not observed in mild/initial states of
depressive disorders.
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Citation
Capponi V, Carrasco C, Macchiavello S, Undurraga J, Campino C, Carvajal C, Gomez T, Weiss C, Aedo I, Vecchiola A, Allende F, Solari S, Fardella C, Baudrand R. Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects. Neuro Endocrinol Lett. 2018 Oct;39(4):288-293. PMID: 30531699.
Keywords
Depression, Mood disorder, Pituitary adrenal system, Cortisol, Metabolic syndrome