Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model

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dc.contributor.authorEngels, Alexander
dc.contributor.authorJoyeux, Luc
dc.contributor.authorVan der Merwe, Johannes
dc.contributor.authorJimenez, Julio
dc.contributor.authorPranpanus, Savitree
dc.contributor.authorBarret, David
dc.contributor.authorConnon, Che
dc.contributor.authorChowdhury, Tina
dc.contributor.authorDavid, Anna
dc.contributor.authorDeprest, Jan
dc.date.accessioned2022-06-02T16:17:56Z
dc.date.available2022-06-02T16:17:56Z
dc.date.issued2018
dc.description.abstractObjective: To evaluate novel sealing techniques for their biocompatibility and sealing capacity of iatrogenic fetal membrane defects in a pregnant rabbit model. Method: At day 23 of gestation (term = d31), a standardized fetoscopy was performed through a 14G cannula. The resulting fetal membrane defect was closed with condensed collagen, collagen with fibrinogen, Tissuepatch, Duraseal, or a conventional collagen plug (Lyostypt) as reference. At d30, the fetuses were harvested and full thickness fetal membrane samples were analyzed. The study consisted of 2 consecutive parts: (1) biocompatibility testing by fetal survival, apoptosis, and infiltration of polymorphonuclear cells in the membranes and (2) the efficacy to seal fetal membrane defects. Results: Three sealants (collagen with fibrinogen, Duraseal, or Lyostypt) were associated with a higher fetal mortality compared to control unmanipulated littermates and hence were excluded from further analysis. Tissuepatch was biocompatible, and amniotic fluid levels were comparable to those of control untouched littermates. Compared to the condensed collagen, Tissuepatch was also easier in surgical handling and induced limited cell proliferation. Conclusion: Tissuepatch had the best biocompatibility and efficacy in sealing an iatrogenic fetal membrane defect in the pregnant rabbit compared to other readily available sealants.es
dc.description.versionVersión publicadaes
dc.identifier.citationEngels AC, Joyeux L, Van der Merwe J, Jimenez J, Pranpanus S, Barrett DW, Connon C, Chowdhury TT, David AL, Deprest J. Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model. Prenat Diagn. 2018 Jan;38(2):99-105. doi: 10.1002/pd.5191es
dc.identifier.urihttps://doi.org/10.1002/pd.5191es
dc.identifier.urihttp://hdl.handle.net/11447/6172
dc.language.isoenes
dc.subjectExtraembryonic Membranes / abnormalitieses
dc.subjectExtraembryonic Membranes / chemistryes
dc.subjectExtraembryonic Membranes / surgeryes
dc.subjectFetal Membranes, Premature Rupture / prevention & controles
dc.subjectFetal Mortalityes
dc.subjectIn Situ Nick-End Labelinges
dc.subjectIatrogenic Diseasees
dc.subjectDisease Models, Animales
dc.subjectCollagenes
dc.titleTissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit modeles
dc.typeArticlees
dcterms.sourcePrenatal diagnosises

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