A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecali

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dc.contributor.authorMunita, José
dc.contributor.authorTran, Truc
dc.contributor.authorDiaz, Lorena
dc.contributor.authorPanesso, Diana
dc.contributor.authorReyes, Jinnethe
dc.contributor.authorMurray, Barbara
dc.contributor.authorArias, Cesar
dc.date.accessioned2017-04-18T13:42:51Z
dc.date.available2017-04-18T13:42:51Z
dc.date.issued2013
dc.description.abstractThe genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
dc.format.extent3
dc.identifier.citationAntimicrobial Agents Chemotherapy, 2013,57(6):2831-3
dc.identifier.urihttp://hdl.handle.net/11447/1164
dc.identifier.urihttp://dx.doi.org/10.1128/AAC.00021-13
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dc.subjectBacterial Proteins/genetics
dc.subjectCodon/genetics
dc.subjectDaptomycin/pharmacology
dc.subjectDrug Resistance, Bacterial/genetics
dc.subjectEnterococcus faecium/drug effects
dc.subjectSequence Deletion/genetics
dc.titleA liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecali
dc.typeArtículo

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