A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant enterococcus faecali
Date
2013
Type:
Artículo
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3
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Journal Title
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Volume Title
Publisher
American Society for Microbiology
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Abstract
The genetic bases for antibiotic tolerance are obscure. Daptomycin (DAP) is a lipopeptide antibiotic with bactericidal activity against enterococci. Using time-kill assays, we provide evidence for the first time that a deletion of isoleucine in position 177 of LiaF, a member of the three-component regulatory system LiaFSR involved in the cell envelope response to antimicrobials, is directly responsible for a DAP-tolerant phenotype and is likely to negatively affect response to DAP therapy.
Description
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Citation
Antimicrobial Agents Chemotherapy, 2013,57(6):2831-3
Keywords
Bacterial Proteins/genetics, Codon/genetics, Daptomycin/pharmacology, Drug Resistance, Bacterial/genetics, Enterococcus faecium/drug effects, Sequence Deletion/genetics