Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease

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dc.contributor.authorEzquer, Fernando
dc.contributor.authorBruna, Flavia
dc.contributor.authorCalligaris, Sebastián
dc.contributor.authorConget, Paulette
dc.contributor.authorEzquer, Marcelo
dc.date.accessioned2017-01-04T17:33:32Z
dc.date.available2017-01-04T17:33:32Z
dc.date.issued2016
dc.descriptionCentro de Medicina Regenerativa
dc.description.abstractChronic alcohol consumption is a major cause of liver disease. The term alcoholic liver disease (ALD) refers to a spectrum of mild to severe disorders including steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. With limited therapeutic options, stem cell therapy offers significant potential for these patients. In this article, we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), based on their potential to differentiate into hepatocytes, their immunomodulatory properties, their potential to promote residual hepatocyte regeneration, and their capacity to inhibit hepatic stellate cells. The perfect match between ALD pathogenesis and MSC therapeutic mechanisms, together with encouraging, available preclinical data, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression.
dc.identifier.citationEzquer F, Bruna F, Calligaris S, Conget P, Ezquer M. Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease. World J Gastroenterol. 2016 Jan 7;22(1):24-36
dc.identifier.urihttp://hdl.handle.net/11447/923
dc.identifier.urihttp://dx.doi.org/ 10.3748/WJG.v22.i1.24
dc.language.isoen_US
dc.publisherWJG Press
dc.subjectAlcoholic liver disease
dc.subjectAlcoholic steatohepatitis
dc.subjectCellular therapy
dc.subjectHepatic function recovery
dc.subjectMesenchymal stem cells
dc.titleMultipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease
dc.typeArtículo

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