Streamlined computational pipeline for genetic background characterization of genetically engineered mice based on next generation sequencing data

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s12864-019-5504-9 - BORIS EDUARDO REBOLLEDO JARAMILLO (1).pdf (3.58 MB)

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2019

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Article

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Artículos Medicina y Ciencias de la Salud

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http://hdl.handle.net/11447/2984

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20 p.

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Abstract

Background: Genetically engineered mice (GEM) are essential tools for understanding gene function and disease modeling. Historically, gene targeting was first done in embryonic stem cells (ESCs) deriv...

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Citation

BMC Genomics, 2019, 20:131

Keywords

Sequencing, Congenic mouse , Knockout mouse , Genomic variation , Genetic interactions , Modifier genes , Genetic background , RNA-Seq variant calling , qPCR validation , Ang , Cdkn1a , Sall2

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