Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet

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dc.contributor.authorRodríguez, Juan
dc.contributor.authorLeiva, Laura
dc.contributor.authorConcha, M
dc.contributor.authorMizón, C
dc.contributor.authorBunout, Daniel
dc.contributor.authorBarrera, Gladys
dc.contributor.authorHirsch, Sandra
dc.contributor.authorJiménez, Teresa
dc.contributor.authorHenríquez, Sandra
dc.contributor.authorUribarri, Jaime
dc.contributor.authorde la Maza, María
dc.date.accessioned2017-05-03T20:13:00Z
dc.date.available2017-05-03T20:13:00Z
dc.date.issued2015
dc.description.abstractDietary intake of advanced glycation end-products (AGEs) increases circulating and tissue levels of these substances, contributing to a state of increased oxidative stress and inflammation. A low dietary AGE intervention has been shown to reduce body AGE content. Mediterranean diets (MD) are theoretically considered low in AGEs, but the specific effects of a MD on AGEs serum levels has not been tested. METHODOLOGY: Forty-seven overweight and obese premenopausal women underwent a three-month calorie restriction treatment (20 kcal/kg initial weight) with a Mediterranean-type diet that excluded wine intake. The adherence to the MD was assessed before and at the end of treatment using an on-line questionnaire, which scores from 0 to 14 (minimal to maximal adherence). Body composition, insulin resistance, lipoproteins and carboxymethyl-lisine (CML) serum levels were measured at both time periods. Serum CML was assessed through ELISA (enzyme-linked immunosorbent assay). Compliance to calorie restriction was assessed according to weight loss (< or > 5% initial weight). RESULTS: Mean body weight, body fat, waist circumference, total cholesterol, triglycerides and serum CML fell significantly, together with an increase in the Mediterranean score, although none of the patients reached the highest score. Significant changes in CML and insulin resistance were observed in 17 women classified as compliant to caloric restriction, but not in the 27 participants who were considered adherent to the MD (according to improvement of the Mediterranean Score). CONCLUSIONS: CML serum levels can be reduced through calorie restricted-Mediterranean-type diet. We could not reach a high enough MD score, so we cannot conclude whether the MD itself has an additive effect to caloric restriction.
dc.format.extent7
dc.identifier.citationRodríguez JM, Leiva Balich L, Concha MJ, Mizón C, Bunout Barnett D, Barrera Acevedo G, Hirsch Birn S, Jiménez Jaime T, Henríquez S, Uribarri J, de la Maza Cave MP. Reduction of serum advanced glycation end-products with a low calorie Mediterranean diet. Nutr Hosp. 2015 Jun 1;31(6):2511-7
dc.identifier.urihttp://hdl.handle.net/11447/1188
dc.identifier.urihttp://dx.doi.org/10.3305/nh.2015.31.6.8936
dc.language.isoen_US
dc.publisherGrupo Arán
dc.subjectCaloric Restriction
dc.subjectDiet, Mediterranean
dc.subjectGlycosylation End Products, Advanced/blood
dc.titleReduction of serum advanced glycation end-products with a low calorie Mediterranean diet
dc.typeArtículo

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