c-Abl activates RIPK3 signaling in Gaucher disease

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2021

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/ 10.1016/j.bbadis.2021.166089
 http://hdl.handle.net/11447/6031

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Abstract

Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain v...

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Yañez MJ, Campos F, Marín T, Klein AD, Futerman AH, Alvarez AR, Zanlungo S. c-Abl activates RIPK3 signaling in Gaucher disease. Biochim Biophys Acta Mol Basis Dis. 2021 May 1;1867(5):166089. doi: 10.1016/j.bbadis.2021.166089. Epub 2021 Feb 4.

Keywords

Death , Gaucher disease (GD) , Lysosomal storage disorders (LSD) , Necroptosis , Receptor interacting serine/threonine kinase 3 (RIPK3) , Tyrosine kinase c-Abl

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