c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder
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Cell Press
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Abstract
The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kina...
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Centro de Genética y Genómica
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Citation
Pablo S. Contreras, Pablo J. Tapia, Lila González-Hódar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis Martinez, Elisa Balboa, Juan Castro, Nancy Leal, Frances M. Platt, Andrzej Sobota, Dominic Winter, Andrés D. Klein, Diego L. Medina, Andrea Ballabio, Alejandra R. Alvarez, Silvana Zanlungo, c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder (2020) iScience 23(11)
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