Carbon monoxide: A new player in the redox regulation of connexin hemichannels

Simple item page
dc.contributor.authorRetamal, Mauricio
dc.contributor.authorLeón-Paravic, Carmen
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorEzquer, Fernando
dc.contributor.authorDel Río, Rodrigo
dc.contributor.authorPupo, Amaury
dc.contributor.authorMartínez, Agustín
dc.contributor.authorGonzález, Carlos
dc.date.accessioned2016-05-16T19:11:03Z
dc.date.available2016-05-16T19:11:03Z
dc.date.issued2015
dc.description.abstractCarbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concentration and activating some kinases, including PKG. The other mechanism of action involves induction of protein carbonylation. CO is known to directly and indirectly modulate the function of ion channels at the plasma membrane, which in turn have important repercussions in the cellular behavior. One group of these channels is hemichannels, which are formed by proteins known as connexins (Cxs). Hemichannel allows not only the flow of ions through their pore but also the release of molecules such as ATP and glutamate. Therefore, their modulation not only impacts cellular function but also cellular communication, having the capability to affect tissular behavior. Here, we review the most recent results regarding the effect of CO on Cx hemichannels and their possible repercussions on pathologies.
dc.identifier.citationRetamal, Mauricio & León-Paravic, Carmen & Ezquer, Marcelo & Ezquer, Fernando & Del Rio, Rodrigo & Pupo, Amaury & Martínez, Agustín & Gonzalez, Carlos. (2015). Carbon Monoxide: A New Player in the Redox Regulation of Cx- Hemichannels. International Union of Biochemistry and Molecular Biology Life. 67. 10.1002/iub.1388.
dc.identifier.urihttp://hdl.handle.net/11447/257
dc.identifier.urihttp://dx.doi.org/10.1002/iub.1388
dc.language.isoen_US
dc.publisherInternational Union of Biochemistry and Molecular Biology
dc.subjectConnexins
dc.subjectHemichannels
dc.subjectRedox potential
dc.subjectGap junction channels
dc.subjectPost-translational modification
dc.subjectGaseous transmitters
dc.titleCarbon monoxide: A new player in the redox regulation of connexin hemichannels
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Carbon monoxide A new player in the redox regulation of connexin hemichannels.pdf
Size:
561.93 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services