Intravenous administration of bone marrow-derived multipotent mesenchymal stromal cells has a neutral effect on obesity-induced diabetic cardiomyopathy

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dc.contributor.authorCalligaris, Sebastián
dc.contributor.authorConget, Paulette
dc.date.accessioned2015-01-13T13:37:05Z
dc.date.available2015-01-13T13:37:05Z
dc.date.issued2013
dc.descriptionInstituto de Ciencias
dc.description.abstractObesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia. Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure. Bone marrow-derived multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSC) are envisioned as a therapeutic tool not only for cardiovascular diseases but also for other degenerative conditions. Our aim was to evaluate whether the intravenous administration of MSC modifies cardiac dysfunction in obese mice. To this end, C57BL/6 mice were fed a regular (normal) or high-fat diet (obese). Obese animals received the vehicle (obese), a single dose (obese + 1x MSC) or three doses (obese + 3x MSC) of 0.5x106 syngeneic MSC. Two to three months following MSC administration, cardiac function was assessed by cardiac catheterization, at basal condition and after a pharmacological stress. Compared to normal mice, obese mice presented hyperglycemia, hyperinsulinemia, hypercholesterolemia and cardiac dysfunction after stress condition. Exogenous MSC neither improved nor impaired this cardiac dysfunction. Thus, intravenous administration of MSC has neutral effect on obesity-induced diabetic cardiomyopathy
dc.identifier.citationBiological Research, 2013, vol. 46, n° 3, p. 251-255
dc.identifier.urihttp://hdl.handle.net/11447/46
dc.identifier.urihttp://dx.doi.org/10.4067/S0716-97602013000300005
dc.language.isoen_US
dc.publisherSociedad de Biología de Chile
dc.subjectObesity
dc.subjectMetabolic syndrome
dc.subjectDiabetic cardiomyopathy
dc.subjectDobutamina
dc.subjectMultipotent mesenchymal stromal cells
dc.titleIntravenous administration of bone marrow-derived multipotent mesenchymal stromal cells has a neutral effect on obesity-induced diabetic cardiomyopathy
dc.typeArtículo

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