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MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy

Show simple item record Ezquer, Marcelo Ezquer, Fernando Arango-Rodríguez, Martha Conget, Paulette 2016-12-19T21:57:50Z 2016-12-19T21:57:50Z 2012
dc.identifier.citation Biological Research, 2012, vol. 45, n° 3, p. 289-296 es_CL
dc.description.abstract complication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. The earliest detectable signs are microalbuminuria and histopathological changes including extracellular matrix deposition, glomerular basement membrane thickening, glomerular and mesangial expansion. Later on macroalbuminuria appears, followed by a progressive decline in glomerular filtration rate and the loss of glomerular podocytes, tubulointerstitial fibrosis, glomerulosclerosis and arteriolar hyalinosis. Tight glycemic and hypertension controls remain the key factors for preventing or arresting the progression of DN. Nevertheless, despite considerable educational effort to control the disease, a significant number of patients not only develop DN, but also progress to chronic kidney disease. Therefore, the availability of a strategy aimed to prevent, delay or revert DN would be highly desirable. In this article, we review the pathophysiological features of DN and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs). The perfect match between them, together with encouraging pre-clinical data available, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage DN onset and progression, not only because of the safety of this procedure, but mainly because of the renoprotective potential of MSCs. es_CL
dc.language.iso en_US es_CL
dc.subject Regenerative medicine es_CL
dc.subject Diabetes mellitus es_CL
dc.subject Diabetic nephropathy es_CL
dc.subject Multipotent mesenchymal stromal cells es_CL
dc.subject Mesenchymal stem cells es_CL
dc.title MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy es_CL
dc.type Artículo es_CL

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