MSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy

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dc.contributor.authorEzquer, Marcelo
dc.contributor.authorEzquer, Fernando
dc.contributor.authorArango-Rodríguez, Martha
dc.contributor.authorConget, Paulette
dc.date.accessioned2016-12-19T21:57:50Z
dc.date.available2016-12-19T21:57:50Z
dc.date.issued2012
dc.description.abstractcomplication is diabetic nephropathy (DN), a clinical syndrome associated with kidney damage and an increased risk of cardiovascular disease. Irrespective of the type of diabetes, DN follows a well-known temporal course. The earliest detectable signs are microalbuminuria and histopathological changes including extracellular matrix deposition, glomerular basement membrane thickening, glomerular and mesangial expansion. Later on macroalbuminuria appears, followed by a progressive decline in glomerular filtration rate and the loss of glomerular podocytes, tubulointerstitial fibrosis, glomerulosclerosis and arteriolar hyalinosis. Tight glycemic and hypertension controls remain the key factors for preventing or arresting the progression of DN. Nevertheless, despite considerable educational effort to control the disease, a significant number of patients not only develop DN, but also progress to chronic kidney disease. Therefore, the availability of a strategy aimed to prevent, delay or revert DN would be highly desirable. In this article, we review the pathophysiological features of DN and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs). The perfect match between them, together with encouraging pre-clinical data available, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage DN onset and progression, not only because of the safety of this procedure, but mainly because of the renoprotective potential of MSCs.
dc.description.urihttp://dx.doi.org/10.4067/S0716-97602012000300010
dc.identifier.citationBiological Research, 2012, vol. 45, n° 3, p. 289-296
dc.identifier.urihttp://hdl.handle.net/11447/905
dc.language.isoen_US
dc.subjectRegenerative medicine
dc.subjectDiabetes mellitus
dc.subjectDiabetic nephropathy
dc.subjectMultipotent mesenchymal stromal cells
dc.subjectMesenchymal stem cells
dc.titleMSC transplantation: a promising therapeutic strategy to manage the onset and progression of diabetic nephropathy
dc.typeArtículo

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