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Your perspective and my benefit: multiple lesion models of self-other integration strategies during social bargaining

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dc.contributor.author Melloni, Margherita
dc.contributor.author Billeke, Pablo
dc.contributor.author Baez, Sandra
dc.contributor.author Hesse, Eugenia
dc.contributor.author De la Fuente, Laura
dc.contributor.author Forno, Gonzalo
dc.contributor.author Birba, Agustina
dc.contributor.author García-Cordero, Indira
dc.contributor.author Serrano, Cecilia
dc.contributor.author Plastino, Angelo
dc.contributor.author Slachevsky, Andrea
dc.contributor.author Huepe, David
dc.contributor.author Sigman, Mariano
dc.contributor.author Manes, Facundo
dc.contributor.author García, Adolfo
dc.contributor.author Sedeño, Lucas
dc.contributor.author Ibáñez, Agustín
dc.date.accessioned 2016-10-17T18:54:00Z
dc.date.available 2016-10-17T18:54:00Z
dc.date.issued 01/09/2016
dc.identifier.citation Brain, 2016, n° 26. Published online: 27 September 2016
dc.identifier.uri http://hdl.handle.net/11447/774
dc.identifier.uri http://dx.doi.org/10.1093/brain/aww231
dc.description.abstract Recursive social decision-making requires the use of flexible, context-sensitive long-term strategies for negotiation. To succeed in social bargaining, participants' own perspectives must be dynamically integrated with those of interactors to maximize self-benefits and adapt to the other's preferences, respectively. This is a prerequisite to develop a successful long-term self-other integration strategy. While such form of strategic interaction is critical to social decision-making, little is known about its neurocognitive correlates. To bridge this gap, we analysed social bargaining behaviour in relation to its structural neural correlates, ongoing brain dynamics (oscillations and related source space), and functional connectivity signatures in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal stroke: behavioural variant frontotemporal dementia, Alzheimer's disease, and frontal lesions. All groups showed preserved basic bargaining indexes. However, impaired self-other integration strategy was found in patients with behavioural variant frontotemporal dementia and frontal lesions, suggesting that social bargaining critically depends on the integrity of prefrontal regions. Also, associations between behavioural performance and data from voxel-based morphometry and voxel-based lesion-symptom mapping revealed a critical role of prefrontal regions in value integration and strategic decisions for self-other integration strategy. Furthermore, as shown by measures of brain dynamics and related sources during the task, the self-other integration strategy was predicted by brain anticipatory activity (alpha/beta oscillations with sources in frontotemporal regions) associated with expectations about others' decisions. This pattern was reduced in all clinical groups, with greater impairments in behavioural variant frontotemporal dementia and frontal lesions than Alzheimer's disease. Finally, connectivity analysis from functional magnetic resonance imaging evidenced a fronto-temporo-parietal network involved in successful self-other integration strategy, with selective compromise of long-distance connections in frontal disorders. In sum, this work provides unprecedented evidence of convergent behavioural and neurocognitive signatures of strategic social bargaining in different lesion models. Our findings offer new insights into the critical roles of prefrontal hubs and associated temporo-parietal networks for strategic social negotiation
dc.language.iso en_US
dc.subject Social decision-making
dc.subject Self-other strategy
dc.subject Lesion model
dc.subject Neurodegeneration
dc.subject Social bargaining
dc.title Your perspective and my benefit: multiple lesion models of self-other integration strategies during social bargaining
dc.type Artículo


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