dc.contributor.author |
Campodónico, Paola |
|
dc.contributor.author |
Tapia, Ricardo |
|
dc.contributor.author |
Suárez, Cristian |
|
dc.date.accessioned |
2022-03-10T13:55:45Z |
|
dc.date.available |
2022-03-10T13:55:45Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Campodónico PR, Tapia RA, Suárez-Rozas C. How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study. Front Chem. 2022 Feb 2;9:740161. doi: 0.3389/fchem.2021.740161 |
es |
dc.identifier.uri |
https://doi.org/10.3389/fchem.2021.740161 |
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dc.identifier.uri |
http://hdl.handle.net/11447/5686 |
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dc.description.abstract |
The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Brønsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes. |
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dc.language.iso |
en |
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dc.subject |
SNAr reactions |
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dc.subject |
brønsted type-plots |
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dc.subject |
hydrogen bond interaction |
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dc.subject |
mechanisms |
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dc.subject |
reactivity |
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dc.title |
How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study |
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dc.type |
Article |
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dc.description.version |
Versión publicada |
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dcterms.source |
Frontiers in chemistry. |
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