How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study
| dc.contributor.author | Campodónico, Paola | |
| dc.contributor.author | Tapia, Ricardo | |
| dc.contributor.author | Suárez, Cristian | |
| dc.date.accessioned | 2022-03-10T13:55:45Z | |
| dc.date.available | 2022-03-10T13:55:45Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Brønsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes. | es |
| dc.description.version | Versión publicada | es |
| dc.identifier.citation | Campodónico PR, Tapia RA, Suárez-Rozas C. How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study. Front Chem. 2022 Feb 2;9:740161. doi: 0.3389/fchem.2021.740161 | es |
| dc.identifier.uri | https://doi.org/10.3389/fchem.2021.740161 | es |
| dc.identifier.uri | http://hdl.handle.net/11447/5686 | |
| dc.language.iso | en | es |
| dc.subject | SNAr reactions | es |
| dc.subject | brønsted type-plots | es |
| dc.subject | hydrogen bond interaction | es |
| dc.subject | mechanisms | es |
| dc.subject | reactivity | es |
| dc.title | How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study | es |
| dc.type | Article | es |
| dcterms.source | Frontiers in chemistry. | es |