Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a SNAr Reaction
Date
2018
Type:
Article
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Abstract
Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.
Description
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Citation
Frontiers in Chemistry. 2018; 6: 509.
Keywords
Solvent effects, Ionic liquids, Catalysis, Anion effect, Preferential solvation