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Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

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dc.contributor.author Duhan, Vikas
dc.contributor.author Khairnar, Vishal
dc.contributor.author Kitanovski, Simo
dc.contributor.author Hamdan, Thamer
dc.contributor.author Klein, Andrés
dc.contributor.author Lang, Judith
dc.contributor.author Ali, Murtaza
dc.contributor.author Adomati, Tom
dc.contributor.author Bhat, Hilal
dc.contributor.author Friedrich, Sarah-Kim
dc.contributor.author Li, Fanghui
dc.contributor.author Krebs, Philippe
dc.contributor.author Futerman, Anthony
dc.contributor.author Addo, Marylyn
dc.contributor.author Hardt, Cornelia
dc.contributor.author Hoffmann, Daniel
dc.contributor.author Lang, Philipp
dc.contributor.author Lang, Karl
dc.date.accessioned 2021-04-06T16:28:06Z
dc.date.available 2021-04-06T16:28:06Z
dc.date.issued 2021
dc.identifier.citation Duhan V, Khairnar V, Kitanovski S, Hamdan TA, Klein AD, Lang J, Ali M, Adomati T, Bhat H, Friedrich SK, Li F, Krebs P, Futerman AH, Addo MM, Hardt C, Hoffmann D, Lang PA, Lang KS. Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Front Immunol. 2021 Jan 27;11:607889. doi: 10.3389/fimmu.2020.607889. PMID: 33584680; PMCID: PMC7873973 es
dc.identifier.uri https://doi.org/10.3389/fimmu.2020.607889 es
dc.identifier.uri http://hdl.handle.net/11447/3852
dc.description Centro de Genética y Genómica (ICIM) es
dc.description.abstract Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection. es
dc.language.iso en es
dc.publisher Frontiers Media SA es
dc.subject KT es
dc.subject CD103 es
dc.subject GWAS es
dc.subject IFN-I es
dc.subject Itgae es
dc.subject Genome wide association screen es
dc.subject mTOR es
dc.subject Vesicular stomatitis virus es
dc.title Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells es
dc.type Article es


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