Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells

Simple item page
dc.contributor.authorDuhan, Vikas
dc.contributor.authorKhairnar, Vishal
dc.contributor.authorKitanovski, Simo
dc.contributor.authorHamdan, Thamer
dc.contributor.authorKlein, Andrés
dc.contributor.authorLang, Judith
dc.contributor.authorAli, Murtaza
dc.contributor.authorAdomati, Tom
dc.contributor.authorBhat, Hilal
dc.contributor.authorFriedrich, Sarah-Kim
dc.contributor.authorLi, Fanghui
dc.contributor.authorKrebs, Philippe
dc.contributor.authorFuterman, Anthony
dc.contributor.authorAddo, Marylyn
dc.contributor.authorHardt, Cornelia
dc.contributor.authorHoffmann, Daniel
dc.contributor.authorLang, Philipp
dc.contributor.authorLang, Karl
dc.date.accessioned2021-04-06T16:28:06Z
dc.date.available2021-04-06T16:28:06Z
dc.date.issued2021
dc.descriptionCentro de Genética y Genómica (ICIM)es
dc.description.abstractEarly and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.es
dc.identifier.citationDuhan V, Khairnar V, Kitanovski S, Hamdan TA, Klein AD, Lang J, Ali M, Adomati T, Bhat H, Friedrich SK, Li F, Krebs P, Futerman AH, Addo MM, Hardt C, Hoffmann D, Lang PA, Lang KS. Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Front Immunol. 2021 Jan 27;11:607889. doi: 10.3389/fimmu.2020.607889. PMID: 33584680; PMCID: PMC7873973es
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.607889es
dc.identifier.urihttp://hdl.handle.net/11447/3852
dc.language.isoenes
dc.publisherFrontiers Media SAes
dc.subjectKTes
dc.subjectCD103es
dc.subjectGWASes
dc.subjectIFN-Ies
dc.subjectItgaees
dc.subjectGenome wide association screenes
dc.subjectmTORes
dc.subjectVesicular stomatitis viruses
dc.titleIntegrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cellses
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.pdf
Size:
2.1 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services