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Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

Show simple item record Erranz, Benjamín Díaz, Franco Donoso, Alejandro Salomón, Tatiana Carvajal, Cristóbal Torres, María Fernanda Cruces, Pablo 2016-05-19T14:42:49Z 2016-05-19T14:42:49Z 2015
dc.identifier.citation Revista Chilena de Pediatría, November–December 2015, vol. 86, n°6, p.404–409 es_CL
dc.identifier.uri es_CL
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract BACKGROUND: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (VT) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. MATERIAL AND METHOD: Twenty large-white piglets (5.2±0.4kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a VT of 6 and 12mL/kg (low and high VT, respectively), both before and after tracheal instillation of polysorbate 20. RESULTS: Before acute lung injury (ALI) induction, modifications of VT did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high VT compared to a low VT (PPV increased from 8.9±1.2 to 12.4±1.1%, and SVV from 8.5±1.0 to 12.7±1.2%, both P<0.01). CONCLUSIONS: This study found that a high VT and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests. es_CL
dc.language.iso en_US es_CL
dc.publisher Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. es_CL
dc.subject Hemodynamics es_CL
dc.subject Preload es_CL
dc.subject Acute lung injury es_CL
dc.subject Mechanical ventilation es_CL
dc.subject Pediatric es_CL
dc.title Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model es_CL
dc.title.alternative Una compliance pulmonar disminuida incrementa los test dinámicos de precarga en un modelo pediátrico de lesión pulmonar aguda es_CL
dc.type Artículo es_CL

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