Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

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dc.contributor.authorErranz, Benjamín
dc.contributor.authorDíaz, Franco
dc.contributor.authorDonoso, Alejandro
dc.contributor.authorSalomón, Tatiana
dc.contributor.authorCarvajal, Cristóbal
dc.contributor.authorTorres, María Fernanda
dc.contributor.authorCruces, Pablo
dc.date.accessioned2016-05-19T14:42:49Z
dc.date.available2016-05-19T14:42:49Z
dc.date.issued2015
dc.descriptionCentro de Medicina Regenerativa
dc.description.abstractBACKGROUND: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (VT) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. MATERIAL AND METHOD: Twenty large-white piglets (5.2±0.4kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a VT of 6 and 12mL/kg (low and high VT, respectively), both before and after tracheal instillation of polysorbate 20. RESULTS: Before acute lung injury (ALI) induction, modifications of VT did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high VT compared to a low VT (PPV increased from 8.9±1.2 to 12.4±1.1%, and SVV from 8.5±1.0 to 12.7±1.2%, both P<0.01). CONCLUSIONS: This study found that a high VT and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests.
dc.identifier.citationRevista Chilena de Pediatría, November–December 2015, vol. 86, n°6, p.404–409
dc.identifier.urihttp://hdl.handle.net/11447/282
dc.identifier.urihttp://dx.doi.org/10.1016/j.rchipe.2015.06.023
dc.language.isoen_US
dc.publisherSociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U.
dc.subjectHemodynamics
dc.subjectPreload
dc.subjectAcute lung injury
dc.subjectMechanical ventilation
dc.subjectPediatric
dc.titleDecreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
dc.title.alternativeUna compliance pulmonar disminuida incrementa los test dinámicos de precarga en un modelo pediátrico de lesión pulmonar aguda
dc.typeArtículo

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