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How right hemisphere damage after stroke can impair speech comprehension

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dc.contributor.author Gajardo-Vidal, Andrea
dc.contributor.author Lorca-Puls, Diego
dc.contributor.author Hope, Thomas M. H.
dc.contributor.author Parker Jones, Oiwi
dc.contributor.author Seghier, Mohamed L.
dc.contributor.author Prejawa, Susan
dc.contributor.author Crinion, Jennifer T.
dc.contributor.author Leff, Alex P.
dc.contributor.author Green, David W.
dc.contributor.author Price, Cathy J.
dc.date.accessioned 2019-08-06T21:36:05Z
dc.date.available 2019-08-06T21:36:05Z
dc.date.issued 2018
dc.identifier.citation Gajardo-Vidal, Andrea, 2018, 35 p.
dc.identifier.uri http://hdl.handle.net/11447/2558
dc.identifier.uri https://doi.org/10.1093/brain/awy270
dc.description.abstract Acquired language disorders after stroke are strongly associated with left hemisphere damage. When language difficulties are observed in the context of right hemisphere strokes, patients are usually considered to have atypical functional anatomy. By systematically integrating behavioural and lesion data from brain-damaged patients with fMRI data from neurologically-normal participants, we investigated when and why right hemisphere strokes cause language disorders. Experiment 1 studied right-handed patients with unilateral strokes that damaged the right (n = 109) or left (n = 369) hemispheres. The most frequently impaired language task was: auditory sentence-to-picture matching after right hemisphere strokes; and spoken picture description after left hemisphere strokes. For those with auditory sentence-to-picture matching impairments after right hemisphere strokes, the majority (n = 9) had normal performance on tests of perceptual (visual or auditory) and linguistic (semantic, phonological or syntactic) processing. Experiment 2 found that these nine patients, had significantly more damage to dorsal parts of the superior longitudinal fasciculus and the right inferior frontal sulcus compared to 75 other patients who also had right hemisphere strokes but were not impaired on the auditory sentence-to-picture matching task. Damage to these right hemisphere regions caused long-term speech comprehension difficulties in 67% of patients. Experiments 3 and 4, used fMRI in two groups of 25 neurologically-normal individuals to show that, within the regions identified by Experiment 2, the right inferior frontal sulcus was normally activated by (i) auditory sentence-to-picture matching and (ii) one-back matching when the demands on linguistic and non-linguistic working memory were high. Together, these experiments demonstrate that the right inferior frontal cortex contributes to linguistic and non-linguistic working memory capacity (executive function) that is needed for normal speech comprehension. Scientifically, our results link previously unrelated literatures on the role of the right inferior frontal cortex in executive processing and the role of executive processing in sentence comprehension; which in turn helps to explain why right inferior frontal activity has previously been reported to increase during recovery of language function after left hemisphere stroke. The clinical relevance of our findings is that the detrimental effect of right hemisphere strokes on language is (i) much greater than expected, (ii) frequently observed after damage to the right inferior frontal sulcus, (iii) task dependent, (iv) different to the type of impairments observed after left hemisphere strokes and (v) can result in long-lasting deficits that are (vi) not the consequence of atypical language lateralisation. Introduction
dc.format.extent 35 p.
dc.language.iso en
dc.subject Right-hemisphere stroke
dc.subject Lesion-deficit mapping
dc.subject fMRI
dc.subject Sentence comprehension
dc.subject Working memory
dc.title How right hemisphere damage after stroke can impair speech comprehension
dc.type Article


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