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Bilateral lung disease, extensive and diffuse. Diagnosis of pulmonary alveolar proteinosis by bronchoscopic cryobiopsy

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dc.contributor.author Gando, Sebastian
dc.contributor.author Dure, Roberto
dc.contributor.author Violi, Damian
dc.contributor.author Vazquez, Bibiana
dc.contributor.author Labarca, Gonzalo
dc.contributor.author Fernández‐Bussy, Sebastián
dc.date.accessioned 2018-01-22T15:05:41Z
dc.date.available 2018-01-22T15:05:41Z
dc.date.issued 2017
dc.identifier.citation Respir Med Case Rep. 2017; 22: 260–262
dc.identifier.uri http://hdl.handle.net/11447/1932
dc.identifier.uri http://dx.doi.org/10.1016/j.rmcr.2017.09.010
dc.description.abstract Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the intra-alveolar accumulation of a proteinaceous phospholipid-laden material called surfactant. Clinically, this disease should be suspected with respiratory failure in association with a crazy paving pattern on high-resolution chest computed tomography. We report a 24-year-old gentleman who was referred to us for a history of respiratory failure, treatment with invasive ventilation and tracheostomy. His blood exams and biochemistry were normal. His infectious and rheumatological panel was negative for a secondary disease. A flexible bronchoscopy with a transbronchial biopsy through a CryoProbe was performed. An anatomopathological analysis was periodic acid-Schiff positive for PAP. A CryoProbe is a recently developed diagnostic tool that improves the diagnostic yield in diffuse lung diseases compared to bronchoscopy with transbronchial biopsy. This method should be considered for patients with diffuse lung disease and PAP.
dc.format.extent 3
dc.language.iso en_US
dc.publisher Elsevier
dc.subject Pulmonary alveolar proteinosis
dc.subject CryoProbe
dc.subject Bronchoscopy
dc.title Bilateral lung disease, extensive and diffuse. Diagnosis of pulmonary alveolar proteinosis by bronchoscopic cryobiopsy
dc.type Artículo


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