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Acido úrico ¿un nuevo factor contribuyente al desarrollo de obesidad?

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dc.contributor.author Valenzuela, Alex
dc.date.accessioned 2018-01-02T13:36:26Z
dc.date.available 2018-01-02T13:36:26Z
dc.date.issued 2016
dc.identifier.citation Revista chilena de nutrición
dc.identifier.uri http://hdl.handle.net/11447/1842
dc.identifier.uri http://dx.doi.org/10.4067/S0717-75182016000300011
dc.description.abstract The excess of uric acid is recognized as a risk factor for diverse metabolic diseases which include gout, urolithiasis, type 2 diabetes, arterial hypertension as well as metabolic syndrome and cardiovascular disease. Current studies suggest that the exaggerated increment in fructose consumption, caused mainly by added suggars, is implicated in the high prevalence of hyperuricemia in the western population.The loss of uricase by mutation of its gene 15 million years ago in the large hominids, including man, has contributed to hyperuricemia, facilitated through the metabolism of fructose the formation of uric acid. It has been proposed that the elevation of uric acid in the remote past was an evolutionary benefit to intensify the lipogenic effects of fructose, allowing humans to survive periods of fruit shortages. However, today the high consumption of fructose and resultant hyperuricemia are a disadvantage, increasing the development of obesity and type 2 diabetes.
dc.format.extent 5
dc.language.iso spa
dc.publisher Sociedad Chilena de Nutrición, Bromatología y Toxicología
dc.subject Uricase
dc.subject Fructose
dc.subject Obesity
dc.subject Uric acid
dc.subject Hyperuricemia
dc.title Acido úrico ¿un nuevo factor contribuyente al desarrollo de obesidad?
dc.title.alternative Uric acid: is it a new contributing factor to the development of obesity?
dc.type Artículo


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